A Study to Evaluate Efficacy and Safety of Three W0027 Regimens in the Treatment of Moccasin Type Tinea Pedis (MTTP)

NCT ID: NCT00509275

Last Updated: 2017-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2008-08-31

Brief Summary

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In this phase Ib, multi-centre, randomized, double-blind, placebo-controlled parallel group study, 120 subjects with moccasin type tinea pedis (MTTP) will be enrolled at approximately 11 centres in the USA, Canada and Australia.

The primary objective of the study is to assess the patient response to three W0027 regimens in subjects with MTTP. Secondary objectives include assessment of the safety, tolerability and skin and nail pharmacokinetics to the three Albaconazole regimens.

Detailed Description

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Conditions

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Tinea Pedis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

W0027

Group Type EXPERIMENTAL

W0027

Intervention Type DRUG

capsule

2

W0027

Group Type EXPERIMENTAL

W0027

Intervention Type DRUG

capsule

3

W0027

Group Type EXPERIMENTAL

W0027

Intervention Type DRUG

capsule

4

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo

Interventions

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W0027

capsule

Intervention Type DRUG

Placebo

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subjects aged 18-65 years, who have been diagnosed with moccasin type tinea pedis (by positive dermatophyte culture, positive potassium hydroxide/calcofluor white preparation, and a Total Signs and Symptoms Score of at least 4).
* Females of childbearing potential must use contraceptive methods .

Exclusion Criteria

* Subjects who are receiving any CYP3A substrates with potential for QT prolongation;
* have used systemic antifungal drugs within 30 days of first dose; or topical antifungals within 2 weeks of first dose.
* Also excluded are those who have a clinically significant medical condition.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role collaborator

Stiefel, a GSK Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lynda Spelman, MD

Role: PRINCIPAL_INVESTIGATOR

South East Dermatology, South East Dermatology, Carina QLD 4152, Australia

Michael Freeman, MD

Role: PRINCIPAL_INVESTIGATOR

The Skin Centre, Benowa QLD 4217, Australia

Peter Foley, MD

Role: PRINCIPAL_INVESTIGATOR

Skin and Cancer Foundation, Carlton VIC 3053 , Australia

Stephen Shumack, MD

Role: PRINCIPAL_INVESTIGATOR

St George Dermatology and Skin Cancer Centre, Kogarah NSW 2217, Australia

Warren Weightman, MD

Role: PRINCIPAL_INVESTIGATOR

Dermatology on Ward, North Adelaide SA 5006, Australia

Debra Breneman, MD

Role: PRINCIPAL_INVESTIGATOR

University Dermatology Consultants, Inc., Cincinnati, OH, 45219, US

Eduardo Tschen, MD

Role: PRINCIPAL_INVESTIGATOR

Albuquerque, NM 87106, US

Yves Poulin, MD

Role: PRINCIPAL_INVESTIGATOR

Centre de Dermatologie de Québec Métropolitain, Quebec, QC, G1V 4X7, Canada

David Gratton, MD

Role: PRINCIPAL_INVESTIGATOR

International Dermatology Research Inc., Montreal, QC, H3H 1V4, Canada

Wayne Gulliver Gulliver, MD

Role: PRINCIPAL_INVESTIGATOR

NewLab Clinical Research, St. John's, NF, A1B 3E1, Canada

Steven Grekin, MD

Role: PRINCIPAL_INVESTIGATOR

13450 East 12 Mile Road, Warren, MI 48088, US

Joseph Fowler, MD

Role: PRINCIPAL_INVESTIGATOR

Dermatology Specialists, 501 South Second Street, Louisville, KY 40202, US

Locations

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Dermatology Specialists

Louisville, Kentucky, United States

Site Status

Warren, Michigan, United States

Site Status

Albuquerque, New Mexico, United States

Site Status

University Dermatology Consultants, Inc.

Cincinnati, Ohio, United States

Site Status

St George Dermatology and Skin Cancer Centre

Kogarah, New South Wales, Australia

Site Status

The Skin Centre

Benowa, Queensland, Australia

Site Status

South East Dermatology

Carina, Queensland, Australia

Site Status

Dermatology on Ward

North Adelaide, South Australia, Australia

Site Status

Skin and Cancer Foundation

Carlton, Victoria, Australia

Site Status

Countries

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United States Australia

Other Identifiers

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W0027-08

Identifier Type: -

Identifier Source: org_study_id

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