A Study of the Effects of GSK189075 on PK Profiles of an Oral Contraceptive Pill When Given to Healthy Female Volunteers

NCT ID: NCT00504816

Last Updated: 2012-06-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Study Completion Date

2008-04-30

Brief Summary

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The purpose of this research study is to demonstrate a lack of effect of multiple doses of GSK189075 on the PK of an oral contraceptive pill in healthy female subjects. To estimate the effects of GSK189075 on hormonal levels and on birth control.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Brevicon

Oral contraceptive used to determine pharmacokinetics when given with GSK189075 to look for interaction.

Group Type OTHER

GSK189075

Intervention Type DRUG

Given with Brevicon to determine any effects of GSK189075 on Brevicon PK.

GSK189075

Given in conjunction with Brevicon to see if GSK189075 interfered with Brevicon drug levels.

Group Type EXPERIMENTAL

Brevicon

Intervention Type DRUG

Given with GSK189075 to determine if GSK189075 exerts an effect on GSK189075 PK.

Interventions

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GSK189075

Given with Brevicon to determine any effects of GSK189075 on Brevicon PK.

Intervention Type DRUG

Brevicon

Given with GSK189075 to determine if GSK189075 exerts an effect on GSK189075 PK.

Intervention Type DRUG

Other Intervention Names

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GSK189075

Eligibility Criteria

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Inclusion Criteria

* healthy, non-smoking menstruating female age 18 to 45 years old, inclusive.
* able to take a specific oral contraceptive \& KG2107494.
* female unable to have any more children, still has ovaries and uterus, and has a negative pregnancy test.
* female who can have children and who has regular periods and are willing to use an oral contraceptive pill and/or have a sterile partner.

Exclusion Criteria

* pregnant or a nursing female.
* female subject able to have children of who is unwilling or unable to use an appropriate method of birth control at least 2 weeks prior to first dose of study drug until completion of the Follow-up visit.
* Have suffered with certain infection within 4 weeks prior to the first dose of study drug
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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GSK Investigational Site

Miramar, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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KG2107494

Identifier Type: -

Identifier Source: org_study_id

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