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N-terminal Pro B-type Natriuretic Peptide (Nt-proBNP) Versus Exercise Test for Evaluation of Acute Chest Pain

NCT ID: NCT00493844

Last Updated: 2016-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

320 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2009-01-31

Brief Summary

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The investigators' objective is to compare a new strategy combining clinical history and NT-proBNP levels versus the usual care, consisting of early exercise testing, for decision making in patients presenting to the emergency department with acute chest pain, non-diagnostic electrocardiogram and normal troponin. The investigators hypothesised that the new strategy combining clinical risk score and NT-proBNP will reduce the number of hospitalisations without increasing the number of events during the follow-up.

Detailed Description

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In patients presenting to the emergency department with acute chest pain, the observation of ischemic changes in the electrocardiogram or troponin elevation prompts hospitalisation and, generally, invasive management. However, decision on admission or discharge is uncertain in the remaining patients. The spectrum of these patients spans from individuals without coronary artery disease to some with high risk unstable angina. An early exercise test is usually performed with the aim of guiding the decision. However, the exercise test is not available 24 hours per day/ 7 days per week, around 40% of the patients show contraindication to exercise and there are inconclusive as well as false-positive results. The limitations of the exercise test can lead to unnecessary hospitalisations. Therefore, there is room for alternative tools. Our objective was to compare a new strategy combining clinical history and NT-proBNP levels versus the usual care, consisting of early exercise testing, for decision making in these patients.

We will randomly compare a new strategy combining a previously published and validated clinical risk score (number of points according to pain characteristics and risk factors) along with NT-proBNP levels, versus the usual strategy using exercise test, for the management of patients presenting to the emergency department with acute chest pain, without ischemia in the electrocardiogram and with normal troponin. In the new strategy, high risk patients (clinical risk score =\>3 points) as well as low risk patients (clinical risk score \<3 points) but with NT-proBNP \>110 ng/L, will be hospitalised; on the other hand, low risk patients (clinical risk score \<3 points) with NT-proBNP \<110 ng/L will be discharged. In the usual strategy, all patients will be allocated to early exercise test; patients will be hospitalised in case of a positive result, inconclusive result \<7 METS or contraindication to exercise, whereas they will be discharged in case of a negative result or inconclusive result with \>7 METS without ischemia induction. The primary endpoint will be hospitalisation during the index episode and the secondary endpoints 6-12 months death or acute myocardial infarction, and 6-12month death, myocardial infarction, postdischarge revascularization or readmission by unstable angina.

Conditions

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Chest Pain

Keywords

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Chest pain Unstable angina NT-proBNP Exercise test.

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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1

Discharge if clinical risk score \<3 points + Nt-proBNP \<110 ng/L

Group Type EXPERIMENTAL

Clinical evaluation + NTproBNP

Intervention Type OTHER

Clinical evaluation + NTproBNP levels

2

Discharge if negative exercise testing

Group Type ACTIVE_COMPARATOR

Exercise testing

Intervention Type OTHER

Exercise testing

Interventions

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Exercise testing

Exercise testing

Intervention Type OTHER

Clinical evaluation + NTproBNP

Clinical evaluation + NTproBNP levels

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Chest pain of possible coronary origin at criterion of cardiology on duty

Exclusion Criteria

* Chest pain of obvious non-coronary origin.
* Electrocardiogram showing ST-segment deviation (=\>1mm) or T-wave inversion (=\>2mm) or atrial fibrillation.
* Troponin elevation at any determination.
* Heart failure at admission.
* Renal failure (creatinine \> 1.3 mg/gl).
* Extracardiac disease with life expectancy less than 1 year.
* Structural heart disease different to ischemic heart disease.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Clinic of Barcelona

OTHER

Sponsor Role collaborator

University of Valencia

OTHER

Sponsor Role lead

Responsible Party

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Juan Sanchis

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Juan Sanchis, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Clínico Universitario. Valencia. Spain

Xavier Bosch, MD

Role: STUDY_CHAIR

Hospital Clínic i Provincial. Barcelona. Spain

Angel Llácer, MD

Role: STUDY_DIRECTOR

Hospital Clínico Universitario. Valencia. Spain.

Locations

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Hospital Clínico Universitario

Valencia, Valencia, Spain

Site Status

Countries

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Spain

References

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Sanchis J, Bodi V, Nunez J, Bertomeu-Gonzalez V, Gomez C, Bosch MJ, Consuegra L, Bosch X, Chorro FJ, Llacer A. New risk score for patients with acute chest pain, non-ST-segment deviation, and normal troponin concentrations: a comparison with the TIMI risk score. J Am Coll Cardiol. 2005 Aug 2;46(3):443-9. doi: 10.1016/j.jacc.2005.04.037.

Reference Type BACKGROUND
PMID: 16053956 (View on PubMed)

Sanchis J, Bodi V, Nunez J, Bertomeu-Gonzalez V, Gomez C, Consuegra L, Bosch MJ, Bosch X, Chorro FJ, Llacer A. Usefulness of early exercise testing and clinical risk score for prognostic evaluation in chest pain units without preexisting evidence of myocardial ischemia. Am J Cardiol. 2006 Mar 1;97(5):633-5. doi: 10.1016/j.amjcard.2005.09.107. Epub 2006 Jan 6.

Reference Type BACKGROUND
PMID: 16490427 (View on PubMed)

Sanchis J, Bodi V, Nunez J, Bosch MJ, Bertomeu-Gonzalez V, Consuegra L, Santas E, Gomez C, Bosch X, Chorro FJ, Llacer A. A practical approach with outcome for the prognostic assessment of non-ST-segment elevation chest pain and normal troponin. Am J Cardiol. 2007 Mar 15;99(6):797-801. doi: 10.1016/j.amjcard.2006.10.042. Epub 2007 Jan 30.

Reference Type BACKGROUND
PMID: 17350368 (View on PubMed)

Sanchis J, Bosch X, Bodi V, Bellera N, Nunez J, Benito B, Ordonez J, Consuegra L, Heras M, Llecer A. Combination of clinical risk profile, early exercise testing and circulating biomarkers for evaluation of patients with acute chest pain without ST-segment deviation or troponin elevation. Heart. 2008 Mar;94(3):311-5. doi: 10.1136/hrt.2007.115626. Epub 2007 Jul 16.

Reference Type BACKGROUND
PMID: 17639094 (View on PubMed)

Sanchis J, Bosch X, Bodi V, Nunez J, Doltra A, Heras M, Mainar L, Santas E, Bragulat E, Garcia-Alvarez A, Carratala A, Llacer A. Randomized comparison between clinical evaluation plus N-terminal pro-B-type natriuretic peptide versus exercise testing for decision making in acute chest pain of uncertain origin. Am Heart J. 2010 Feb;159(2):176-82. doi: 10.1016/j.ahj.2009.11.010.

Reference Type RESULT
PMID: 20152214 (View on PubMed)

Other Identifiers

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09-27-06

Identifier Type: -

Identifier Source: org_study_id