PK, PD and Safety of Multiple Doses of V1512 Tablets in PD Patients Compared to Standard Levodopa/Carbidopa Oral Tablets

NCT ID: NCT00491998

Last Updated: 2011-07-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 27 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-11-30
• Study Completion Date: 2007-11-30

Brief Summary

The purpose of the study is to determine if the pharmacokinetic profile of V1512 is similar or better than existing medications for the treatment of Parkinson's Disease

Detailed Description

The pharmacokinetics of V1512 effervescent tablet has been evaluated in healthy volunteers, however not fully in PD patients. This study aims to evaluate the PK profiles in PD patients of different dosing schedules of V1512 effervescent tablet compared to the profiles after standard L-dopa/carbidopa (Sinemet) over the course of the day. Two dosing schedules have been chosen to evaluate a possible relation between dosing interval and 'ON' time, with and without associated dyskinesia. Similar dosing schedules with the comparator Sinemet are commonly employed in the treatment of fluctuating PD patients. Patients assigned to cohort 3 will also take a dose of entacapone concomitantly with each dose of V1512 or Sinemet, thereby allowing the kinetics and dynamics of.V1512 and Sinemet to be compared in the presence of COMT inhibition.

Safety and tolerability of the dosing regimens in patients will also be assessed further in this double-blind study

Conditions

Parkinson's Disease

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

2-hourly dosing

6 Doses of IMP at 2-hourly intervals

Group Type: EXPERIMENTAL

V1512

Intervention Type: DRUG

6 doses of IMP at 2-hourly intervals

3-hourly dosing

4 doses of IMP at 3-hourly intervals

Group Type: EXPERIMENTAL

V1512

Intervention Type: DRUG

3-hourly dosing

3-hourly dosing plus Entacapone

4 doses of IMP plus Entacapone at 3-hourly intervals

Group Type: ACTIVE_COMPARATOR

V1512 and Entacapone

Intervention Type: DRUG

4 doses of IMP and Entacapone at 3-hourly intervals

Interventions

V1512

6 doses of IMP at 2-hourly intervals

Intervention Type: DRUG

V1512

3-hourly dosing

Intervention Type: DRUG

V1512 and Entacapone

4 doses of IMP and Entacapone at 3-hourly intervals

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Male or female, >30 years of age of any race;

2. A Body Mass Index between 18.5 and 29.9 kg/m2 (inclusive);

3. Clinical diagnosis according to the Brain Bank diagnostic criteria of idiopathic Parkinson's Disease (2 of 3 cardinal symptoms - bradykinesia, rigidity, tremor -must be present, with a positive response to L-dopa);

4. Presence of fluctuations in motor performance with >2 hours inclusive of daytime OFF episodes (not applicable for cohort 1 patients);

5. At least 1 hour delay to ON time with afternoon doses;

6. Discontinued use of COMT inhibitors (cathecol-o-methyl transferase) for at least 2 weeks prior to study entry (not applicable for cohort 3 patients);

7. Stable doses of dopamine agonists or selegiline for at least 2 weeks before entry into the study;

8. Stable comorbidity for 4 weeks;

9. Female patients must be of non-childbearing potential (post-menopausal or physically incapable of childbearing);

10. Willing and able to give informed consent according to national legal requirements prior to initiation of any study-related procedures

Exclusion Criteria

1. Clinically relevant abnormal vital sign values or safety laboratory data.

2. Patients who smoke and are unable to refrain from smoking during the in-clinic period

3. Diagnosis of atypical parkinsonism;

4. A history and/or the presence of gastro-intestinal disorders (or surgery) that could interfere with absorption of the test medication;

5. A history of intolerance or clinically relevant allergy to L-dopa and/or carbidopa taken in any formulation or combination;

6. A history of intolerance or clinically relevant allergy to entacapone or any ingredients of Comtan (cohort 3 patients only)

7. Any other condition which, in the opinion of the Investigator, would interfere with optimal participation in the study e.g. inability to complete patient diary;

8. Participation in any clinical study or receiving treatment with another investigational drug within 30 days or 5 half lives (whichever is longer) before the screening visit;

9. Blood donation within 3 months before study participation;

10. History of neuroleptic malignant syndrome (NMS) or NMS-like syndromes, or non-traumatic rhabdomyolysis;

11. Patients taking non-selective MAO inhibitors;

12. Patients with a history of, or clinical indication of, narrow angle glaucoma;

13. Patients with a history of, or clinical indication of, malignant melanoma;

14. Patients with a history of, or clinical indication of, depression or psychosis;

15. Patients taking iron containing medications (ferrous sulphate, ferrous gluconate)

• Minimum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cita NeuroPharmaceuticals

INDUSTRY

Sponsor Role: collaborator

Syneos Health

OTHER

Sponsor Role: collaborator

Vernalis (R&D) Ltd

INDUSTRY

Sponsor Role: lead

Principal Investigators

Fabrizio Stocchi, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

IRCCS San Raffaele

Locations

IRCCS San Raffaele Pisana

Roma, Rome, Italy

Countries

Italy

References

Stocchi F, Vacca L, Grassini P, Pawsey S, Whale H, Marconi S, Torti M. L-Dopa Pharmacokinetic Profile with Effervescent Melevodopa/Carbidopa versus Standard-Release Levodopa/Carbidopa Tablets in Parkinson's Disease: A Randomised Study. Parkinsons Dis. 2015;2015:369465. doi: 10.1155/2015/369465. Epub 2015 Jun 10.

Reference Type: DERIVED

PMID: 26171276 (View on PubMed)

Other Identifiers

V1512-2PD01

Identifier Type: -

Identifier Source: org_study_id