Clinical Trial on Alzheimer Disease, Presbycusis and Hearing Aids

NCT ID: NCT00488007

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

51 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2013-09-30

Brief Summary

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This is a 12-months' randomized clinical trial that aims at studying the benefit of bilateral hearing aids in hearing impaired patients suffering from a slight to moderate stage Alzheimer disease.

The benefit of this intervention will be studied in the cognitive, behavioural, quality of life and economic fields.

2groups are involved in this trial: Intervention group: 12 months' treatment with active hearing aids, fitted hearing impairment Control group: 6 months' treatment with placebo hearing aids, followed with 6 months' active hearing aids, fitted hearing impairment

Detailed Description

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Conditions

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Alzheimer Disease Presbycusis

Keywords

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Alzheimer disease Cognitive impairment Sensorineural hearing loss Hearing aids

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Active Hearing aids

Active

Group Type EXPERIMENTAL

Hearing aids used : PHONAK Savia and Valeo

Intervention Type DEVICE

5 hours per day during the first 6 months (active or inactive upon randomization) 5 hours per day during the last 6 months (active)

Inactive Hearing aids

Hearing aids turned off

Group Type PLACEBO_COMPARATOR

Hearing aids used : PHONAK Savia and Valeo

Intervention Type DEVICE

5 hours per day during the first 6 months (active or inactive upon randomization) 5 hours per day during the last 6 months (active)

Interventions

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Hearing aids used : PHONAK Savia and Valeo

5 hours per day during the first 6 months (active or inactive upon randomization) 5 hours per day during the last 6 months (active)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* \> 65 year-old
* Medical diagnosis of Alzheimer disease
* 15 ≤ MMSE ≤ 25
* No hearing aids in the last 2 years
* Motivated caregiver living with the patient
* Sensorineural hearing loss

Exclusion Criteria

* Beginning of an anticholinesterasic treatment in the last 6 months
* Change in the anticholinesterasic treatment in the last 2 months
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marc BONNEFOY, MD

Role: PRINCIPAL_INVESTIGATOR

Hospices Civils de Lyon

Locations

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Xavier PERROT

Lyon, , France

Site Status

Countries

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France

References

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Adrait A, Perrot X, Nguyen MF, Gueugnon M, Petitot C, Collet L, Roux A, Bonnefoy M; ADPHA study group. Do Hearing Aids Influence Behavioral and Psychological Symptoms of Dementia and Quality of Life in Hearing Impaired Alzheimer's Disease Patients and Their Caregivers? J Alzheimers Dis. 2017;58(1):109-121. doi: 10.3233/JAD-160792.

Reference Type RESULT
PMID: 28269769 (View on PubMed)

Nguyen MF, Bonnefoy M, Adrait A, Gueugnon M, Petitot C, Collet L, Roux A, Perrot X; ADPHA study group. Efficacy of Hearing Aids on the Cognitive Status of Patients with Alzheimer's Disease and Hearing Loss: A Multicenter Controlled Randomized Trial. J Alzheimers Dis. 2017;58(1):123-137. doi: 10.3233/JAD-160793.

Reference Type RESULT
PMID: 28387664 (View on PubMed)

Other Identifiers

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2006.414

Identifier Type: -

Identifier Source: org_study_id