A Study of MK0359 in Patients With Chronic Asthma (0359-013)

NCT ID: NCT00482898

Last Updated: 2015-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-09-30

Study Completion Date

2003-04-30

Brief Summary

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A study to test the effect of MK0359 in lessening the symptoms of asthma as compared to placebo.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Interventions

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MK0359

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* You are between the ages of 18 and 45
* You have had a history for at least a year of COPD symptoms
* Your current asthma treatment is limited to short-acting beta-agonists(such as albuterol)
* You have a history of smoking one pack of cigarettes per day for 7 years
* You will not be away from home for more than 5 days during the study

Exclusion Criteria

* You are unwilling to limit your alcohol use to less than 5 drinks per week
* You have been in a research study with an investigational drug or vaccine in the last 4 weeks
* You have donated blood in the last 4 weeks
* You have been hospitalized or had major surgery in the last 4 weeks
* You have been treated in the emergency room within the last 4 weeks or hospitalized within the last 3 months for your asthma
* You have a history of heart problems in the last 6 months
* You have a history of stomach problems
* You are unwilling to avoid grapefruit juice throughout the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

References

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Lu S, Liu N, Dass SB, Reiss TF, Knorr BA. Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma. Respir Med. 2009 Mar;103(3):342-7. doi: 10.1016/j.rmed.2008.10.024. Epub 2009 Jan 8.

Reference Type BACKGROUND
PMID: 19135348 (View on PubMed)

Other Identifiers

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MK0359-013

Identifier Type: -

Identifier Source: secondary_id

2007_575

Identifier Type: -

Identifier Source: secondary_id

0359-013

Identifier Type: -

Identifier Source: org_study_id

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