Phenylephrine Versus Norepinephrine in Septic Shock

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2007-03-31

Brief Summary

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Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.

Detailed Description

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Conditions

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Septic Shock

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Phenylephrine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Clical diagnosis of Septic Shock
* norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmHg and central venous pressure = 8-12 mmHg).

Exclusion Criteria

* Age \< 18 years
* Pregnancy
* Present or suspected acute coronary artery disease
* Present or suspected acute mesenteric ischemia.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Andrea Morelli, MD

Role: PRINCIPAL_INVESTIGATOR

Departement of Anesthesiology and Intensive Care of the University of Rome "La Sapienza"

Locations

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Department of Anesthesiology and Intensive care of the University of Rome "La Sapienza"

Rome, , Italy

Site Status

Countries

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Italy

Other Identifiers

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1125

Identifier Type: -

Identifier Source: org_study_id