Lilly's Emotional and Physical Symptoms of Depression Study (LEAPS)

NCT ID: NCT00479726

Last Updated: 2007-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

8000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-08-31

Study Completion Date

2005-01-31

Brief Summary

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To assess the effectiveness of duloxetine administered once daily in patients with Major Depressive Disorder in a practice based setting

Detailed Description

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To assess physical and emotional symptoms of depressed patients

Conditions

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Major Depressive Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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duloxetine hydrochloride

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Meet criteria for major depressive disorder according to the DSM-IV diagnostic criteria
* Outpatients at least 18 years of age
* Sign the informed consent
* All females must test negative for a urine pregnancy test at visit 1. Females of child bearing potential must agree to utilize medically acceptable and reliable means of birth control
* Have a level of understanding sufficient to communicate with the investigator and are able to complete all patient self-rated scales in the study

Exclusion Criteria

* Are investigator site personnel directly affiliated with the study or immediate family
* Are employed by Eli Lilly and Company
* Have received treatment within the last 30 days or are currently enrolled in a study with a drug that has not received regulatory approval for any indication at time of study entry
* Current substance dependence, excluding nicotine and caffeine
* Treatment with a monoamine oxidase inhibitor within 14 days prior to visit 1 or potential need to use an MAOI within 5 days after discontinuation of study drug
* Acute liver injury or severe (Child-Pugh Class C) cirrhosis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9AM - 5PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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For additional information regarding investigative sites for this trial,contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM - 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician

Indianapolis, Indiana, United States

Site Status

Countries

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United States

References

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Wohlreich MM, Wiltse CG, Desaiah D, Ye W, Robinson RL, Kroenke K, Kornstein SG, Greist JH. Duloxetine in practice-based clinical settings: assessing effects on the emotional and physical symptoms of depression in an open-label, multicenter study. Prim Care Companion J Clin Psychiatry. 2007;9(4):271-9. doi: 10.4088/pcc.v09n0404.

Reference Type DERIVED
PMID: 17934551 (View on PubMed)

Other Identifiers

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F1J-MC-HMCY

Identifier Type: -

Identifier Source: secondary_id

8300

Identifier Type: -

Identifier Source: org_study_id

NCT00479414

Identifier Type: -

Identifier Source: nct_alias

NCT00479453

Identifier Type: -

Identifier Source: nct_alias