Morphine Analgesia in Patients With Acute Appendicitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

71 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-01-31

Study Completion Date

2005-03-31

Brief Summary

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The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.

Detailed Description

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Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose.

Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.

Conditions

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Appendicitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Interventions

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Morphine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* clinical signs of acute appendicitis
* planned for appendectomy
* supposed to wait for at least 1 hour in the ED before operation

Exclusion Criteria

* suspicion to perforated appendicitis
* being under the age of 13
* pregnancy (according to history and ß-HCG result)
* opium addiction
* systolic blood pressure of less than 90 mmHG
* known cases of chronic obstructive pulmonary disease (COPD)
* known sensitivity to morphine
* history of sickle cell disease
* self administration of analgesics before enrollment
* refusal to participate

Minimum Eligible Age

13 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Asieh Golozar, MD

Role: PRINCIPAL_INVESTIGATOR

Tehran University of Medical Sciences

Locations

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Sina General Hospital

Tehran, Tehran Province, Iran

Site Status

Countries

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Iran

References

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Amoli HA, Golozar A, Keshavarzi S, Tavakoli H, Yaghoobi A. Morphine analgesia in patients with acute appendicitis: a randomised double-blind clinical trial. Emerg Med J. 2008 Sep;25(9):586-9. doi: 10.1136/emj.2007.050914.

Reference Type DERIVED

PMID: 18723709 (View on PubMed)

Other Identifiers

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AG11

Identifier Type: -

Identifier Source: org_study_id