Study of Genetic Polymorphisms in Thai HIV-1 Infected Patients on SQV/r

NCT ID: NCT00476502

Last Updated: 2012-04-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-02-28

Study Completion Date

2008-12-31

Brief Summary

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Study of genetic polymorphisms of CYP #A and MDR-1 genes in Thai HIV-1 infected patients on saquinavir/ritonavir.

Detailed Description

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Genetic polymorphisms will be investigated by polymerase-chain reaction (PCR) and drug levels of saquinavir will be determined by high phase liquid chromatography with UV-detected (HPLC).

Conditions

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HIV Infections

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

patients involved in structured interruption therapy

identify genetic polymorphism in Thai HIV infected

Intervention Type GENETIC

Gene sequencing of Cyp450 metabolic pathway

Interventions

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identify genetic polymorphism in Thai HIV infected

Gene sequencing of Cyp450 metabolic pathway

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* HIV-infected persons who have been enrolled in the Staccato study
* On low-dose ritonavir boosted saquinavir at the time blood samples are collected

Exclusion Criteria

* Inability to understand the nature and extent of the study and the procedures required
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Roche Pharma AG

INDUSTRY

Sponsor Role collaborator

The HIV Netherlands Australia Thailand Research Collaboration

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kiat Ruxrungtham, MD

Role: PRINCIPAL_INVESTIGATOR

The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT)

Locations

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The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT)

Bangkok, Bangkok, Thailand

Site Status

Countries

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Thailand

Related Links

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http://www.hivnat.org

The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT)

Other Identifiers

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HIV-NAT 031

Identifier Type: -

Identifier Source: org_study_id

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