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Does Topical Steroid Treatment Impair the Adrenal Function?

NCT ID: NCT00476489

Last Updated: 2007-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-05-31

Brief Summary

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The purpose of this study is to determine if topical steroids treatment for different skin diseases suppress the adrenal cortisol production.

Detailed Description

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Adrenocortical suppression is a potential complication of systemic corticosteroid treatement but also of non systemic therapy like topical therapy.

The normalcy of hypothalamic-pituitary-adrenal axis ( HPA axis) of patients with chronic skin diseases like atopic dermatitis, pemphigus or psoriasis which are treated with topical steroids, will be assessed with the low dose (1mcg) adrenocortocotropin ( ACTH) stimulation test. During this test serum cortisol levels are measured before, 30 and 60 mn after intravenous administration of 1mcg of ACTH (synacthen).The results will be compared with age and sex matched subjects with normal HPA axis as assessed by low dose ACTH stimulation test.

Conditions

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Hypothalamus-Pituitary-Adrenal Axis Assessement Topical Steroid Therapy in Chronic Skin Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* patients receiving daily topical steroids for at least two weeks on 10% or more of body surface.

Exclusion Criteria

* patients treated with any form of corticosteroids except topical steroids.
* patients with known pituitary disease
* pregnant patients
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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HaEmek Medical Center, Israel

OTHER

Sponsor Role lead

Principal Investigators

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Avraham Ishay, MD

Role: PRINCIPAL_INVESTIGATOR

haemek medical center

Locations

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Haemek Medical Center

Afula, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Avraham Ishay, MD

Role: CONTACT

[email protected]
972-4-6495556

Rafael Luboshitzky, MD

Role: CONTACT

[email protected]

Facility Contacts

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Avraham Ishay, MD

Role: primary

[email protected]
972-4-6495556

Other Identifiers

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02307EMC

Identifier Type: -

Identifier Source: org_study_id