Older Adult Training Study With Creatine and CLA

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-08-31

Study Completion Date

2004-09-30

Brief Summary

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We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (\> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Detailed Description

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Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).

Conditions

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Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Interventions

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Training

Intervention Type BEHAVIORAL

Creatine Monohydrate, Conjugated Linoleic Acid

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy,
* Ambulatory,
* Recreationally active,
* Community dwelling

Exclusion Criteria

* Evidence of coronary heart disease;
* Congestive heart disease;
* Uncontrolled hypertension;
* Chronic obstructive pulmonary disease;
* Diabetes mellitus;
* Renal failure;
* Major orthopedic disability; and
* Smoking

Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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Mark A Tarnopolsky, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

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McMaster University Medical Center

Hamilton, Ontario, Canada

Site Status

Countries

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Canada

References

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Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, Pearce E, Roy B, Doherty T. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS One. 2007 Oct 3;2(10):e991. doi: 10.1371/journal.pone.0000991.

Reference Type DERIVED

PMID: 17912368 (View on PubMed)

Other Identifiers

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