Study Comparing 17B Estradiol/TMG CC 1mg Vs. Tibolone In Postmenopausal Women

NCT ID: NCT00472004

Last Updated: 2010-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

204 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-02-28

Study Completion Date

2009-12-31

Brief Summary

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This is a Phase IV prospective, randomized, open label, comparative, multicenter study in generally healthy postmenopausal women receiving Totelle (17B Estradiol/TMG CC (1mg)) and Livial (Tibolone).

Detailed Description

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Conditions

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Vasomotor Symptoms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

17B Estradiol (1mg) / (0.125 mg) Trimegestone (TMG) Continuous combined, 1 Daily, 1 year duration

Group Type ACTIVE_COMPARATOR

17B Estradiol (1mg) / (0.125 mg) TMG Continuous combined (Totelle)

Intervention Type DRUG

17B Estradiol (1mg) / (0.125 mg) TMG Continuous combined, 1 Daily, 1 year duration

2

Tibolone 2.5 mg 1 daily, 1 year duration

Group Type ACTIVE_COMPARATOR

Tibolone (Livial)

Intervention Type DRUG

Tibolone 2.5 mg 1 daily, 1 year duration

Interventions

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17B Estradiol (1mg) / (0.125 mg) TMG Continuous combined (Totelle)

17B Estradiol (1mg) / (0.125 mg) TMG Continuous combined, 1 Daily, 1 year duration

Intervention Type DRUG

Tibolone (Livial)

Tibolone 2.5 mg 1 daily, 1 year duration

Intervention Type DRUG

Other Intervention Names

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Totelle Livial

Eligibility Criteria

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Inclusion Criteria

* Generally healthy postmenopausal women
* Last natural (without exogenous hormone therapy) menstrual cycle completed at least 12 consecutive months prior to screening and without any other kind of gynecological bleeding during this same period
* At least 1 year of natural occurring amenorrhea

Exclusion Criteria

* Known or suspected estrogen-dependent neoplasia
* Endometrial hyperplasia
* Any malignancy with the exception of a history of basal cell carcinoma of the skin
Minimum Eligible Age

45 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Wyeth is now a wholly owned subsidiary of Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Pfizer, Inc

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Monterrey, Nuevo León, Mexico

Site Status

Countries

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Mexico

Related Links

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Other Identifiers

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B2481004

Identifier Type: -

Identifier Source: secondary_id

0753T-101800

Identifier Type: -

Identifier Source: org_study_id