Pazopanib in Treating Patients With Metastatic Urothelial Cancer

NCT ID: NCT00471536

Last Updated: 2014-05-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 19 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-08-31
• Study Completion Date: 2013-12-31

Brief Summary

This phase II trial is studying the side effects and how well pazopanib works in treating patients with metastatic urothelial cancer. Pazopanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Detailed Description

PRIMARY OBJECTIVES:

I. Assess the anti tumor activity and toxicity profile of pazopanib hydrochloride in patients with metastatic urothelial cancer.

SECONDARY OBJECTIVES:

I. Evaluate the pharmacokinetics of pazopanib hydrochloride in these patients. II. Evaluate pre- and post-treatment changes in circulating endothelial cells, monocytes and platelets, and angiogenesis-related factors in these patients.

OUTLINE: This is a multicenter study. Patients receive oral pazopanib hydrochloride once daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Patients undergo blood collection periodically for correlative studies and pharmacological studies. Samples are analyzed for vascular endothelial growth factor (VEGF) and soluble VEGF receptor II concentration via ELISA. Circulating endothelial cells are also measured.

After completion of study treatment, patients are followed for 1 year.

Conditions

Distal Urethral Cancer; Proximal Urethral Cancer; Recurrent Bladder Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Stage IV Bladder Cancer; Transitional Cell Carcinoma of the Bladder; Urethral Cancer Associated With Invasive Bladder Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment (enzyme inhibitor therapy)

Patients receive 800 mg oral pazopanib hydrochloride once daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Group Type: EXPERIMENTAL

pazopanib hydrochloride

Intervention Type: DRUG

800 mg Given orally

Interventions

pazopanib hydrochloride

800 mg Given orally

Intervention Type: DRUG

Other Intervention Names

GW786034B; Votrient

Eligibility Criteria

Inclusion Criteria

• Histologically or cytologically confirmed transitional cell cancer of the urothelium or bladder

• Metastatic disease
• Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 2.0 cm by conventional techniques OR ≥ 1.0 cm by spiral CT scan
• No known brain metastases
• ECOG performance status 0-2
• Life expectancy ≥ 12 weeks
• Platelet count ≥ 100,000/mm^3
• WBC ≥ 3,000/mm^3
• Absolute neutrophil count ≥ 1,500/mm^3
• Bilirubin normal
• AST and ALT ≤ 2.5 times upper limit of normal (ULN)
• Creatinine normal OR creatinine clearance ≥ 60 mL/min
• PT/INR/PTT ≤ 1.2 times ULN
• No proteinuria > 1+ on two consecutive dipsticks measured ≥ 1 week apart
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No history of allergic reactions attributed to compounds of similar chemical or biological composition to pazopanib hydrochloride or other agents used in the study
• No condition that impairs the ability to swallow and retain pazopanib hydrochloride tablets, including any of the following:

• Gastrointestinal tract disease resulting in an inability to take oral medication
• Requirement for IV alimentation
• Prior surgical procedures affecting absorption
• Active peptic ulcer disease
• No uncontrolled illness that would limit compliance with study therapy including, but not limited to, any of the following:

• Ongoing or active infection
• Psychiatric illness or social situations
• No QTc prolongation (defined as a QTc interval ≥ 480 msecs) or other significant ECG abnormalities (e.g., frequent ventricular ectopy, evidence of ongoing myocardial ischemia)
• No other conditions, including any of the following:

• Serious or non-healing wound, ulcer, or bone fracture
• Abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 28 days
• Cerebrovascular accident within the past 6 months
• Myocardial infarction, cardiac arrhythmia, or admission for unstable angina within the past 12 weeks
• Venous thrombosis within the past 12 weeks
• New York Heart Association (NYHA) class III or IV heart failure

• Asymptomatic NYHA class II heart failure on treatment allowed
• No other active second malignancy other than non-melanoma skin cancer

• Patients are not considered to have an active malignancy if they have completed anti-cancer therapy and are considered by their physician to be ≤ 30% risk of relapse
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C) and recovered
• At least 4 weeks since prior radiotherapy
• Prior palliative radiotherapy to metastatic lesions allowed provided there is ≥ 1 measurable and/or evaluable lesion(s) that has not been irradiated
• At least 4 weeks since prior surgery
• One prior chemotherapy regimen for metastatic urothelial or bladder cancer
• More than 12 weeks since prior cardiac angioplasty or stenting
• Prior adjuvant or neoadjuvant therapy allowed
• No prior experimental treatment for metastatic disease
• No other prior or concurrent investigational agents
• No concurrent combination antiretroviral therapy for HIV-positive patients
• No concurrent CYP2C9 substrates, including any of the following:

• Anticoagulants (e.g., warfarin [therapeutic doses only])

• Low molecular weight heparin and prophylactic low-dose warfarin (≤ 2 mg daily) allowed
• Oral hypoglycemics (e.g., glipizide, glyburide, tolbutamide, glimepiride, or nateglinide)
• Ergot derivatives (e.g., dihydroergotamine, ergonovine, ergotamine, or methylergonovine)
• Antipsychotics (e.g., pimozide or clozapine)
• Erectile dysfunction agents (e.g., sildenafil, tadalafil, or vardenafil)
• Antiarrhythmics (e.g., bepridil, flecainide, lidocaine, mexiletine, amiodarone, quinidine, or propafenone)
• Immune modulators (e.g., cyclosporine, tacrolimus, or sirolimus)
• Miscellaneous drugs (e.g., theophylline, quetiapine, risperidone, tacrine, or atomoxetine)
• No other concurrent anticancer agents or therapies
• No concurrent medications that are associated with a risk of QTc prolongation and/or Torsades de Pointes

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ulka Vaishampayan

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

Mayo Clinic in Florida

Jacksonville, Florida, United States

Johns Hopkins University

Baltimore, Maryland, United States

Wayne State University

Detroit, Michigan, United States

Mayo Clinic

Rochester, Minnesota, United States

Metro-Minnesota CCOP

Saint Louis Park, Minnesota, United States

Cox Medical Center

Springfield, Missouri, United States

Washington University School of Medicine

St Louis, Missouri, United States

Chinese University of Hong Kong-Prince of Wales Hospital

Shatin, Hong Kong, China

Gangnam Severance Hospital

Seoul, , South Korea

Countries

United States; China; South Korea

Other Identifiers

NCI-2009-00203

Identifier Type: REGISTRY

Identifier Source: secondary_id

CDR0000543460

Identifier Type: -

Identifier Source: secondary_id

MAYO-MC0553

Identifier Type: -

Identifier Source: secondary_id

MC0553

Identifier Type: OTHER

Identifier Source: secondary_id

7661

Identifier Type: OTHER

Identifier Source: secondary_id

N01CM62205

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCI-2009-00203

Identifier Type: -

Identifier Source: org_study_id