Bromfenac BID Plus Prednisolone Acetate BID Versus Bromfenac BID Plus Prednisolone QID for the Prevention of Cystoid Macular Edema and Retinal Thickening

NCT ID: NCT00469781

Last Updated: 2008-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

95 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2008-09-30

Brief Summary

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The objective of this study is to determine if twice-daily dosing of prednisolone (Pred Forte) is as effective as four-times-daily dosing of prednisolone for the prevention of retinal thickening and cystoid macular edema (CME) when either regimen is used concomitantly with twice-daily bromfenac.

Detailed Description

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Conditions

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Cystoid Macular Edema, Retinal Thickening

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Investigators

Study Groups

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1

Group Type ACTIVE_COMPARATOR

1. Pred Forte

Intervention Type DRUG

Group 1 Instill one drop in the eye that was operated on four times a day starting on day of surgery and use for four weeks.

Group 2 Instill one drop in the eye that was operated on twice a day starting on day of surgery and use for four weeks.

2

Group Type OTHER

2. Xibrom (Bromfenac)

Intervention Type DRUG

Group 1 and 2: 1 drop(Instill one drop in the eye that was operated on twice daily)3 days prior to surgery and 4 doses during dilation immediately before the procedure. Use for 4 weeks after surgery.

Interventions

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2. Xibrom (Bromfenac)

Group 1 and 2: 1 drop(Instill one drop in the eye that was operated on twice daily)3 days prior to surgery and 4 doses during dilation immediately before the procedure. Use for 4 weeks after surgery.

Intervention Type DRUG

1. Pred Forte

Group 1 Instill one drop in the eye that was operated on four times a day starting on day of surgery and use for four weeks.

Group 2 Instill one drop in the eye that was operated on twice a day starting on day of surgery and use for four weeks.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* · Male or female \> 18 years of age scheduled to undergo cataract surgery

* Must be in good general health. Patients with systemic diseases will be enrolled only if there are no ocular manifestations of their disease (ie diabetics with normal retinal exams)
* Expected visual outcome of 20/25 or better.
* Ability to provide informed consent and likely to complete all study visits

Exclusion Criteria

* · Known contraindication to any study medication or any of their components

* Uncontrolled systemic disease
* Required use of ocular medications other than the study medications during the study
* Abnormal pre-operative OCTs
* Diabetic patients with a history of macular edema or diabetic retinopathy
* AMD, epi-retinal membranes, retinal vein occlusion, or any pre-existing macular disease
* Only one eye of each patient can be enrolled
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Center For Excellence In Eye Care

OTHER

Sponsor Role lead

Responsible Party

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The Center for Excellence in Eye Care

Principal Investigators

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Carlos Buznego, MD

Role: PRINCIPAL_INVESTIGATOR

The Center for Excellence in Eye Care

Locations

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The Center for Excellence in Eye Care

Miami, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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5306

Identifier Type: -

Identifier Source: org_study_id