A Sub-study to LMF237A2302 to Assess the Effect of 24 Weeks Treatment With Initial Combination of Vildagliptin Plus Metformin

NCT ID: NCT00468039

Last Updated: 2020-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

94 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-03-06

Study Completion Date

2008-06-06

Brief Summary

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This study will evaluate the effects of treatment with vildagliptin and metformin as initial combination in newly diagnosed patients with type 2 diabetes who have very high levels of HbA1c and/or fasting plasma glucose.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Keywords

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metformin vildagliptin initial combination

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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vildagliptin + metformin

Group Type EXPERIMENTAL

vildagliptin + metformin

Intervention Type DRUG

Interventions

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vildagliptin + metformin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female (non-fertile or of childbearing potential using a medically approved birth control method) patients with type 2 diabetes
* Diagnosis of type 2 diabetes for at least 4 weeks prior to study entry
* Body mass index 22-40 kg/meter squared
* HbA1c \> 11% and/or FPG \>270 mg/dL

Exclusion Criteria

* Pregnant or lactating female
* History of type 1 diabetes
* Evidence of significant diabetic complications
* Treatment with insulin or any other oral antidiabetic agent
Minimum Eligible Age

18 Years

Maximum Eligible Age

78 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

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Diabetes and Glandular Disease Research Associates

San Antonio, Texas, United States

Site Status

Countries

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United States

References

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Bosi E, Dotta F, Jia Y, Goodman M. Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2009 May;11(5):506-15. doi: 10.1111/j.1463-1326.2009.01040.x. Epub 2009 Mar 23.

Reference Type RESULT
PMID: 19320662 (View on PubMed)

Related Links

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https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=2651

Results for CLMF237A2302S1 from the Novartis Clinical Trials website

Other Identifiers

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CLMF237A2302S1

Identifier Type: -

Identifier Source: org_study_id