Holotranscobalamin Remains Unchanged During Pregnancy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

1995-01-31

Study Completion Date

1997-12-31

Brief Summary

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Background and objective: Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins, transcobalamin (total TC, holoTC) and haptocorrin (total HC, holoHC). TC transports cobalamin into the cells. The function of HC is unknown, but in contrast to TC it binds both cobalamins and cobalamin analogues.

Design and methods: Healthy pregnant women (N=141) had blood samples drawn at 18th, 32nd, 39th gestation week and 8 weeks postpartum. The protein moiety of TC and HC (total and holo) was measured by in-house ELISA methods.

Detailed Description

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Background and objective: Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins, transcobalamin (total TC, holoTC) and haptocorrin (total HC, holoHC). TC transports cobalamin into the cells. The function of HC is unknown, but in contrast to TC it binds both cobalamins and cobalamin analogues.

Design and methods: Healthy pregnant women (N=141) had blood samples drawn at 18th, 32nd, 39th gestation week and 8 weeks postpartum. The protein moiety of TC and HC (total and holo) was measured by in-house ELISA methods.

Conditions

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Vitamin B12 Deficiency

Keywords

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Pregnancy holotranscobalamin cobalamin vitamin B12 analogues reference interval

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Danish healthy Caucasian women \>18 years of age with previous uncomplicated pregnancies and deliveries and presently with a normal pregnancy.

Exclusion Criteria

* \>4 cigarettes smoked per day,
* Treatment with vitamin B12, folic acid or acetyl salicylic acid,
* Impaired renal function and clinically significant vaginal haemorrhage before first visit as well as blood haemoglobin \<6.4 mmol/L at first visit.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Principal Investigators

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Nils Milman, MD

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Locations

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Nils Milman

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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KA-93140

Identifier Type: -

Identifier Source: org_study_id