Erlotinib and Bevacizumab in Treating Patients With Stage IV Melanoma

NCT ID: NCT00466687

Last Updated: 2013-07-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2004-09-30
• Study Completion Date: 2008-09-30

Brief Summary

RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving erlotinib together with bevacizumab may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving erlotinib together with bevacizumab works in treating patients with stage IV melanoma.

Detailed Description

OBJECTIVES:

Primary

• Determine the overall response rate, response duration, and frequency of progression-free survival at 6 months in patients with stage IV melanoma treated with erlotinib hydrochloride and bevacizumab.
• Determine objective responses in patients treated with this regimen.

Secondary

• Determine the overall safety and tolerability of this regimen in these patients.
• Evaluate tissue blocks for EGFR by monoclonal antibody H11 (DAKO) or fluorescence in situ hybridization(FISH)7p12-specific probe-overexpression or amplification in patients treated with this regimen.

OUTLINE: This is a multicenter study.

Patients receive oral erlotinib hydrochloride once daily on days 1-28 and bevacizumab IV over 30-90 minutes on days 1 and 15. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Patients undergo tissue collection to analyze EGFR by monoclonal antibody H11 (DAKO) or fluorescence in situ hybridization (FISH) 7p12-specific probe-overexpression or amplification. Biological markers AKT, MAPK, p27, p21, CD13, CD34, and factor VIII are also measured.

After completion of study treatment, patients are followed periodically.

Conditions

Melanoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Therapeutic Intervention

Tarceva and Avastin:

• Tarceva: 150mg PO, days 1-28
• Avastin: 10mg/kg, IV infusion, days 1,15 Regimen will be repeated every 28 days = 1 course

Group Type: EXPERIMENTAL

bevacizumab

Intervention Type: BIOLOGICAL

10mg/kg, slow IV infusion, Days 1 and 14

erlotinib hydrochloride

Intervention Type: DRUG

150mg PO qd

fluorescence in situ hybridization

Intervention Type: GENETIC

Targeting multiple genetic aberrations in isolated tumor cells.

gene expression analysis

Intervention Type: GENETIC

gene expression analysis

immunologic technique

Intervention Type: OTHER

immunologic technique

laboratory biomarker analysis

Intervention Type: OTHER

laboratory biomarker analysis

biopsy

Intervention Type: PROCEDURE

biopsy

Interventions

bevacizumab

10mg/kg, slow IV infusion, Days 1 and 14

Intervention Type: BIOLOGICAL

erlotinib hydrochloride

150mg PO qd

Intervention Type: DRUG

fluorescence in situ hybridization

Targeting multiple genetic aberrations in isolated tumor cells.

Intervention Type: GENETIC

gene expression analysis

gene expression analysis

Intervention Type: GENETIC

immunologic technique

immunologic technique

Intervention Type: OTHER

laboratory biomarker analysis

laboratory biomarker analysis

Intervention Type: OTHER

biopsy

biopsy

Intervention Type: PROCEDURE

Other Intervention Names

Avastin; Tarceva

Eligibility Criteria

Inclusion Criteria

• Measurable Stage IV melanoma
• Easter Cooperative Oncology Group (ECOG) Performance Status must be 0-1
• Good organ function as demonstrated by, Creatinine <2.mg/dl, AST or ALT <5 times upper limit of normal for subjects with documented liver metastases; <2.5 times the upper limit of normal (ULN) for subjects without evidence of liver metastases, bilirubin<2.0mg/dl,, absolute neutrophil count (ANC)>1500/ul, platelets>75k/ul, hemoglobin (Hgb)>9 (may be transfused to obtain)
• Prior therapy: adjuvant interferon (IFN) allowed; no more than one prior regimen for advanced stage IV disease
• Patients must have a life expectancy of >3 months
• Patients with brain metastases are eligible only if they fulfill the following: resected or stereotactic treatment a minimum of 3 months previously and no active CNS disease since then; brain metastases treated greater than 6 months ago without evidence of progression or hemorrhage, <1cm in size per lesion (up to 3 lesions), and off all steroids
• Patients may not have received other agents, either investigational or marketed, which act by either EGFr inhibition or anti-angiogenesis mechanisms. Other epidermal growth factor receptor (EGFR) inhibitors include (but are not limited to): Iressa, erbitux, CI-1033. Angiogenesis inhibitors include (but are not limited to): SU5416, SU6668, SU 0122348, CP547632, VEGF Trap, anti-integrin αVβ3.
• Recovered from toxicity of major surgery (4 wks), chemotherapy or biologic therapy (4 wks), and/or radiation therapy (2 wks)
• No active other malignancy within 12 months
• No active systemic infection
• Over age of 18 years and signed IRB approved informed consent

Exclusion Criteria

• Subjects meeting any of the following criteria (3.2.2-3.2.16) are ineligible for study entry
• Compromised renal or hepatic function as defined by Creatinine >2.0mg/dl, aspartate transaminase (AST) or alanine transaminase (ALT) >5 times upper limit of normal for subjects with documented liver metastases; >2.5 times the upper limit of normal (ULN) for subjects without evidence of liver metastases
• Patient may not be part of any other investigational studies
• internationalized normal ratio (INR) > 1.5
• Patients with PEG or G-tube are ineligible.
• Major surgical procedure, open biopsy; or significant traumatic injury within 28 days, or anticipation of need for major surgical procedure during the course of the study
• Any non-healing wound, ulcer, or bone fracture.
• Any clinical evidence or history of a bleeding diathesis or coagulopathy.
• Patients with a history of deep vein thrombosis or thromboembolic disease within the past 6 months.
• History of acute myocardial infarction within 6 months. In addition, patients are ineligible if they have clinically significant cardiovascular disease ((e.g., uncontrolled hypertension [blood pressure of >160/110 mmHg on medication], New York Heart Association (NYHA) Grade II or greater congestive heart failure, serious cardiac dysrhythmia requiring medication, or peripheral vascular disease (Grade II or greater)
• Patients with > 1+ proteinuria will have 24-hour urine collection; for protein. Patients with ≥ 1gm protein/24 hrs will be excluded
• If child bearing age must not be pregnant or nursing and use methods to prevent pregnancy
• History or evidence upon physical examination of central nervous system (CNS) disease (e.g., primary brain tumor, seizures not controlled with standard medical therapy, or history of stroke)
• Inability to comply with study and/or follow-up procedures
• History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that might affect the interpretation of the results of the study or render the subject at high risk from treatment complications.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

Vanderbilt-Ingram Cancer Center

OTHER

Sponsor Role: lead

Responsible Party

Jeffrey A. Sosman, MD

Professor of Medicine; Director, Melanoma and Tumor Immunotherapy

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jeffrey A. Sosman, MD

Role: PRINCIPAL_INVESTIGATOR

Vanderbilt-Ingram Cancer Center

Locations

Vanderbilt-Ingram Cancer Center - Cool Springs

Nashville, Tennessee, United States

Vanderbilt-Ingram Cancer Center at Franklin

Nashville, Tennessee, United States

Sarah Cannon Research Institute

Nashville, Tennessee, United States

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, United States

Countries

United States

Other Identifiers

VU-VICC-MEL-0418

Identifier Type: -

Identifier Source: secondary_id

VU-IRB-040468

Identifier Type: -

Identifier Source: secondary_id

VICC MEL 0418

Identifier Type: -

Identifier Source: org_study_id