Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour Application

NCT ID: NCT00466570

Last Updated: 2013-06-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Brief Summary

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Topical ophthalmic antibiotics are common prescribed just prior to eye surgery to lower the risk of infection. Previous studies have suggested that antibiotics containing a preservative (Zymar) kill bacteria much quicker than those without a preservative (Vigamox). The purpose of this research is to compare how quickly to the two commonly prescribed antibiotics eliminate bacteria from the eye surface.

Detailed Description

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Conditions

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Conjunctical Flora

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Interventions

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gatifloxacin, moxifloxacin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age- older than 50 years of age
* Diagnosis- Cataract or had cataract surgery

Exclusion Criteria

* Systemic or topical antibiotic treatment within 30 days
* Use of systemic or topical steroids
* Active ocular infection
* Ocular surgery in the past 6 months
* Allergy to fluoroquinolones
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Christopher Ta

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Christopher Ta, MD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

References

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Ta CN, He L, Nguyen E, De Kaspar HM. Prospective randomized study determining whether a 3-day application of ofloxacin results in the selection of fluoroquinolone-resistant coagulase-negative Staphylococcus. Eur J Ophthalmol. 2006 May-Jun;16(3):359-64.

Reference Type BACKGROUND
PMID: 16761235 (View on PubMed)

Mino de Kaspar H, Koss MJ, He L, Blumenkranz MS, Ta CN. Antibiotic susceptibility of preoperative normal conjunctival bacteria. Am J Ophthalmol. 2005 Apr;139(4):730-3. doi: 10.1016/j.ajo.2004.10.007.

Reference Type BACKGROUND
PMID: 15808182 (View on PubMed)

de Kaspar HM, Kreidl KO, Singh K, Ta CN. Comparison of preoperative conjunctival bacterial flora in patients undergoing glaucoma or cataract surgery. J Glaucoma. 2004 Dec;13(6):507-9. doi: 10.1097/01.ijg.0000137872.19942.cf.

Reference Type BACKGROUND
PMID: 15534478 (View on PubMed)

Ta CN, Chang RT, Singh K, Egbert PR, Shriver EM, Blumenkranz MS, Mino de Kaspar H. Antibiotic resistance patterns of ocular bacterial flora: a prospective study of patients undergoing anterior segment surgery. Ophthalmology. 2003 Oct;110(10):1946-51. doi: 10.1016/s0161-6420(03)00735-8.

Reference Type BACKGROUND
PMID: 14522770 (View on PubMed)

Ta CN, Egbert PR, Singh K, Shriver EM, Blumenkranz MS, Mino De Kaspar H. Prospective randomized comparison of 3-day versus 1-hour preoperative ofloxacin prophylaxis for cataract surgery. Ophthalmology. 2002 Nov;109(11):2036-40; discussion 2040-1. doi: 10.1016/s0161-6420(02)01236-8.

Reference Type BACKGROUND
PMID: 12414411 (View on PubMed)

Other Identifiers

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8924

Identifier Type: -

Identifier Source: org_study_id

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