Prospective, Randomized, Controlled, Clinical Study on Tolerability and Efficacy of hMG-IBSA

NCT ID: NCT00464607

Last Updated: 2007-04-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-12-31

Study Completion Date

2005-04-30

Brief Summary

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Purpose of the study is the evaluation of the tolerability (both local and systemic) and the clinical efficacy (in terms oocytes recovered) of subcutaneously versus intramuscularly administered Merional® (IBSA, Lugano - CH) in patients undergoing controlled ovarian hyperstimulation (COH) in an ART programme (IVF).

Detailed Description

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Conditions

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Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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hMG-IBSA

Intervention Type DRUG

Ovarian stimulation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Female patients
* aged between 20 and 40 years
* undergoing ovarian stimulation for the purposes of oocyte retrieval in an assisted conception programme
* Body Mass Index (BMI) 20-28 kg/m2
* early follicular phase FSH level \< 9 IU/l.

Exclusion Criteria

* ascertained or presumptive hypersensitivity to the active principle and/or their ingredients
* primary ovarian failure
* ovarian cysts or enlargement not due to polycystic ovarian syndrome
* oocyte donation
* abnormal bleeding of undetermined origin
* patients who have exhibited poor response or requiring doses of more than 300 IU daily in previous treatment cycles or those who have received similar therapies (previous treatment cycles) in the 30 days prior to the beginning of the present study
* uncontrolled thyroid or adrenal dysfunction
* neoplasia
* severe impairment of the renal and/or hepatic functions
* diabetes and active thrombophlebitis, cardiopathies and epilepsy
* presence of clinically significant systemic disease or any contraindication of being pregnant and/or carrying out a pregnancy to term
* presence of any anatomical abnormality of the reproductive system
* being pregnant or breastfeeding
* menopause
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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IBSA Institut Biochimique SA

INDUSTRY

Sponsor Role lead

Principal Investigators

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Nicola Ragni, Prof.

Role: PRINCIPAL_INVESTIGATOR

Ospedale S.Martino - Genova (Italy)

Luigi Fedele, Prof.

Role: PRINCIPAL_INVESTIGATOR

Ospedale S. Paolo - Milano (Italy)

Giuseppe De Placido, Prof.

Role: PRINCIPAL_INVESTIGATOR

Ospedale Federico II - Napoli (Italy)

Marco Massobrio, Prof.

Role: PRINCIPAL_INVESTIGATOR

Ospedale S. Anna - Torino (Italy)

Locations

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Ospedale S. Martino

Genova, Genova, Italy

Site Status

Ospedale S. Paolo

Milan, Milano, Italy

Site Status

Ospedale Federico II

Napoli, Napoli, Italy

Site Status

Ospedale S. Anna

Torino, Torino, Italy

Site Status

Countries

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Italy

Other Identifiers

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00IF/HMG06

Identifier Type: -

Identifier Source: org_study_id