Postoperative Delirium at Heidelberg's Intensive Care Unit -New Diagnostic Markers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Study Start Date

2005-05-31

Brief Summary

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Summary:

Postoperative delirium is a highly prevalent disease (10-30% prevalence) after surgery in intensive care unit, however, it is often misdiagnosed and mistreated. The aim of the present project is to investigate risk factors for postoperative delirium in more detail, to evaluate respective cognitive test systems and to measure EEG activity parallel to patients' serum anticholinergic activity. The pathophysiology of delirium is unknown up to now: a possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely hypothesis. Therefore, the measurement of peripheral serum anticholinergic activity could be a new prognostic factor for evaluation of delirium. Because delirium is also associated with higher postoperative mortality and morbidity, with delayed functional recovery, and postoperative delirium makes patient management much more difficult, increases costs, and, above all, causes severe discomfort to the patient new interdisciplinary diagnostic strategies are necessary to resolve this problem.

Detailed Description

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Conditions

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Postoperative Delirium

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* All patients at Intensive Care Unit over a defined time period
* Over 18 years old

Exclusion Criteria

* Elective heart and vascular patients

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Markus A Weigand, PhD, MD

Role: PRINCIPAL_INVESTIGATOR

Medical Faculty, Clinic of Anesthesiology, University of Heidelberg

Konstanze Plaschke, Prof.

Role: PRINCIPAL_INVESTIGATOR

Clinic of Anesthesiology

Locations

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Intensive Care Unit, Clinic of Anesthesiology

Heidelberg, Heidelberg, Germany

Site Status

Countries

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Germany

References

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Plaschke K, Kopitz J, Mattern J, Martin E, Teschendorf P. Increased cortisol levels and anticholinergic activity in cognitively unimpaired patients. J Neuropsychiatry Clin Neurosci. 2010 Fall;22(4):433-41. doi: 10.1176/jnp.2010.22.4.433.

Reference Type DERIVED

PMID: 21037129 (View on PubMed)

Other Identifiers

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196/2004

Identifier Type: -

Identifier Source: org_study_id