Case-Control-Study on the Breast Cancer Risk of Mirena® Compared With Copper IUDs

NCT ID: NCT00461253

Last Updated: 2016-01-25

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

25565 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-10-31

Study Completion Date

2014-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this study is to determine the breast cancer risk of Mirena® users compared to copper intrauterine device (IUD) users in a community-based case-control study.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a community-based case-control study in Germany and Finland. Cases will be identified from cancer registries, tumor centers and breast centers. Matched controls will be accrued from the same region as the case came from. Breast cancer cases and their controls are women under 50 years of age without known history of malignancies.

Cases are women with a breast cancer who are younger than 50 years of age at cancer diagnosis. The breast cancer was diagnosed between January 2000 and December 2007. Only alive cases and cases in a sufficiently good health status to be interviewed are eligible for the study.

Controls are women without a breast cancer diagnosis who are younger than 50 years of age at the time of the interview. About 3 controls matched by year of birth and region will be allocated to each case.

A standardized questionnaire will be used for all breast cancer cases and controls. The questionnaire will be mailed to cases and controls.

Study participants will be asked for their informed consent. Data confidentiality according to national laws will be ensured by the field organizations.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Breast Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Breast Cancer Cases

Levonorgestrel-releasing IUD

Intervention Type DEVICE

This is a case-control-study; strictly speaking the category "intervention type" does not apply to this study.

Copper IUD

Intervention Type DEVICE

This is a case-control-study; strictly speaking the category "intervention type" does not apply to this study.

2

Matched Controls for Breast Cancer Cases

Levonorgestrel-releasing IUD

Intervention Type DEVICE

This is a case-control-study; strictly speaking the category "intervention type" does not apply to this study.

Copper IUD

Intervention Type DEVICE

This is a case-control-study; strictly speaking the category "intervention type" does not apply to this study.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Levonorgestrel-releasing IUD

This is a case-control-study; strictly speaking the category "intervention type" does not apply to this study.

Intervention Type DEVICE

Copper IUD

This is a case-control-study; strictly speaking the category "intervention type" does not apply to this study.

Intervention Type DEVICE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Mirena

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* cases: women with a breast cancer who are younger than 50 years of age at cancer diagnosis
* controls: women without a breast cancer diagnosis who are younger than 50 years at the time of the interview

Exclusion Criteria

* women who are not willing to participate
Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Bayer

INDUSTRY

Sponsor Role collaborator

Center for Epidemiology and Health Research, Germany

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Juergen Dinger, MD, PhD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Juergen Dinger, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Center for Epidemiology and Health Research

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Center for Epidemiology and Health Research

Berlin, , Germany

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Germany

References

Explore related publications, articles, or registry entries linked to this study.

Dinger J, Bardenheuer K, Minh TD. Levonorgestrel-releasing and copper intrauterine devices and the risk of breast cancer. Contraception. 2011 Mar;83(3):211-7. doi: 10.1016/j.contraception.2010.11.009. Epub 2011 Jan 7.

Reference Type RESULT
PMID: 21310281 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ZEG2006_02

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Mirena Observational Program
NCT00883662 COMPLETED
European Active Surveillance Study of LCS12
NCT02146950 ACTIVE_NOT_RECRUITING