Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)
NCT ID: NCT00457379
Last Updated: 2007-08-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2007-04-30
2008-04-30
Brief Summary
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The purpose of the present study is to characterize the quality of HDL-cholesterol in patients with coronary artery disease and normal blood HDL-cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-cholesterol in these patients. Additionally, the researchers aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with coronary artery disease and the changes dependent on physical activity of patients.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
NONE
Interventions
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physical exercise
Eligibility Criteria
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Inclusion Criteria
* Normal HDL-cholesterol levels in blood:
* \> 40 mg/dl (1.03 mmol/L) in males
* \> 50 mg/dl (1.29 mmol/L) in females
Exclusion Criteria
* Acute coronary syndrome
* Unstable angina pectoris
* Myocardial infarction during the last 8 weeks
* Therapy with niacin
* Active infections
* Ventricular arrhythmias
* Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 95 mmHg
* Cancer
* Pregnant or lactating
* Alcoholism
21 Years
70 Years
ALL
Yes
Sponsors
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Hannover Medical School
OTHER
Principal Investigators
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Helmut Drexler, MD
Role: STUDY_DIRECTOR
Hannover Medical School
Ulf Landmesser, MD
Role: PRINCIPAL_INVESTIGATOR
Hannover Medical School
Kristina Sonnenschein, MD
Role: PRINCIPAL_INVESTIGATOR
Hannover Medical School
Locations
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Hannover Medical School
Hanover, , Germany
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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4031214
Identifier Type: -
Identifier Source: org_study_id