Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2006-08-31

Brief Summary

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paraoxonase 1 is involved to prevent LDL and HDL oxidation,so increase of it's activity leads to lower risk of coronary heart disease.In postmenopausal women ,we have decrease of paraoxonase1 activity and soy proteins may increase paraoxonase1 activity

Detailed Description

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In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group.

Conditions

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Postmenopausal Hyperlipidemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Interventions

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soy consumption

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Cessation of menes for more than 1 year, elevation for more than 1 year
* Elevation of FSH level
* Total cholesterol
* Triglyceride more than 200 mg/dl

Exclusion Criteria

* Chronic disease (heart disease, cancer, diabetes, hepatic, kidney and thyroid disease)
* Antihypertensive drugs
* Antibiotics
* Lipid lowering drugs
* Sex hormone treatment
* Hysterectomy
* Diet rich in soy protein

Minimum Eligible Age

51 Years

Maximum Eligible Age

57 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Principal Investigators

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farzad Shidfar, Ph.D

Role: STUDY_CHAIR

assistant professor of nutrition,Iran university of medical sciences

Other Identifiers

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1344

Identifier Type: -

Identifier Source: org_study_id