Atorvastatin in Moderate Active Crohns Disease

NCT ID: NCT00454545

Last Updated: 2007-10-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2007-10-31

Brief Summary

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Open pilot study to collect information regarding the effect of atorvastatin on patients with active Crohns disease.

Detailed Description

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Conditions

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Crohns Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Atorvastatin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Crohns disease
* C-reactive protein level \> 2 mg/L in absence of an infection
* Fecal calprotectin \> 250 mg/kg or CDAI \> 150

Exclusion Criteria

* CDAI \> 450
* Prednisolone dosage above 15 mg/day
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Skane University Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Olof Grip, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Malmo University Hospital, Region Skåne

Anders Bredberg, MD, PhD

Role: STUDY_CHAIR

Malmo University Hospital, Region Skåne

Gunnel Bredberg, MD, PhD

Role: STUDY_CHAIR

Malmo University Hospital, Region Skåne

Locations

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Department of Medicine, Division of Gastroenterology and Hepatology

Malmo, , Sweden

Site Status

Countries

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Sweden

References

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Grip O, Janciauskiene S. Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease. PLoS One. 2009;4(5):e5263. doi: 10.1371/journal.pone.0005263. Epub 2009 May 6.

Reference Type DERIVED
PMID: 19421322 (View on PubMed)

Other Identifiers

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010-02

Identifier Type: -

Identifier Source: org_study_id