Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-04-30

Study Completion Date

2010-04-30

Brief Summary

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The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Detailed Description

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Elevated serum brain natriuretic peptide (BNP) levels released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload. However, limited data suggest that serum BNP may be elevated in patients with systemic sclerosis (SSc), especially with RV dysfunction. The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in SSc patients and to establish whether it reflects the severity of RV overload.

Conditions

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Systemic Sclerosis

Keywords

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systemic sclerosis pulmonary hypertension echocardiography N-Terminal proBNP

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of systemic sclerosis

Exclusion Criteria

* Cardiovascular disorders other than pulmonary hypertension
* Significant pulmonary function abnormalities
* Impaired renal function

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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Michał Ciurzyński, M.D., Ph.D

Role: PRINCIPAL_INVESTIGATOR

Medical University of Warsaw

Locations

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Michał Ciurzyński

Warsaw, Lindleya 4, Poland

Site Status RECRUITING

Countries

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Poland

Central Contacts

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Ciurzyński Michał, M.D, Ph.D

Role: CONTACT

Phone: +48 22 502 11 44

Email: [email protected]

Piotr Pruszczyk, M.D, Ph.D.