Kinetics of D-Dimers After Abdominal Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-02-28

Study Completion Date

2007-10-31

Brief Summary

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The purpose of this study is to investigate the natural kinetics of D-dimers that occur after abdominal surgery.

Detailed Description

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Venous thromboembolism (VTE) is a potentially fatal disease with an estimated incidence of 0.1%. One third of the VTE occur as pulmonal embolism with a mortality up to 25% (White RH. Circulation 107:2003)

Serum d-dimer levels are used as sensitive marker for the diagnosis of VTE (Kelly J et al. Arch Intern Med, 162: 2002). Because of its sensitivity, the determination of serum D-dimer levels is an accepted method to exclude VTE in the outpatient setting meaning that VTE may be excluded in case of normal D-dimer levels (Kelly J. Lancet 359: 2002). The specificity of the D-dimer testing, however, is low. This is true especially in the postoperative phase. The interpretation of elevated D-dimer levels in surgical patients remains elusive.

The natural kinetics of D-dimers after surgery is not known. The question to what extent D-dimer levels rise after surgery and how long it may take D-dimer levels to return to normal after surgery is not yet determined. This information is needed to be able to use D-dimer testing for VTE diagnosis in surgical patients.

In this study, D-dimer levels are measured in surgical patients immediately before (day 0) and repeatedly after surgery. D-dimer level measurement will be stopped after D-dimer levels returned to normal.

Conditions

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Natural Kicetics of d-Dimers After Surgery

Keywords

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D-dimers surgery kinetics

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients undergoing elective surgery

Exclusion Criteria

* age \< 18 years
* patients not speaking german
* patients involved in another study
* pregnancy
* concommitant inflammatory disease
* patients with oral anticoagulation
* patients having received fresh frozen plasma

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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Daniel Dindo, MD

Role: PRINCIPAL_INVESTIGATOR

University of Zurich

Locations

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Univeryity Hospital, Clinic for Visceral- and Transplantation Surgery

Zurich, Canton of Zurich, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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StV 31-2006

Identifier Type: -

Identifier Source: org_study_id