Phase 2a Randomized, Double-Blind Study of Oleoyl-Estrone in Male Morbidly Obese Adults

NCT ID: NCT00449254

Last Updated: 2007-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Brief Summary

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Multi-center, multiple-dose, randomized, double-blind, three-arm, placebo-controlled study of fixed-dose repeated oral dosing for 30 days of 10 mg and 30 mg MP-101 and placebo in obese subjects.

Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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oleoyl-estrone (MP-101)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subject is willing and able to provide signed informed consent.
* Subject is a male and is between 18-60 years of age.
* Subject is obese as defined as a BMI of 40 - 55.
* Subject is reasonably healthy and have a reasonably acceptable medical history
* Subject has a stable weight for the past 30 days per subject report.
* Subject who has at least one factor of the metabolic
* Subject exhibits stable behavior patterns with regard to smoking and exercise
* Subject can read, speak and write the English language and agrees to follow study procedures.

Exclusion Criteria

* Subjects who have received any investigational medication within 3 months prior to administration of study drug
* Subjects with confirmed positive results of UDS or Alcohol
* Subjects who are unwilling to return to the clinical research center on specified days during the treatment periods.
* Subjects who have taken exclusionary medication
* Subjects with any clinically significant laboratory abnormality or illness which, in the opinion of the Investigator, would contraindicate study participation
* Subjects who have a history of testing positive for Hepatitis B virus, Hepatitis C virus, or HIV.
* Subject has been involved in a formal or informal (self-imposed) diet regimen within the last 30 days.
* Subject has a confirmed diagnosis or history of cancer, with the exception of nonmelanoma skin cancer.
* Subject is otherwise unsuitable for the study, in the opinion of the investigator.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Manhattan Pharmaceuticals

INDUSTRY

Sponsor Role lead

Locations

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St. Luke's-Roosevelt Hospital

New York, New York, United States

Site Status

Research Across America

Dallas, Texas, United States

Site Status

Jean Brown Research

Salt Lake City, Utah, United States

Site Status

Countries

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United States

Other Identifiers

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MAN-OE-US-04

Identifier Type: -

Identifier Source: org_study_id