Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis

NCT ID: NCT00440661

Last Updated: 2010-03-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-03-31

Study Completion Date

2008-10-31

Brief Summary

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Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.

Detailed Description

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Conditions

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Osteoarthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Diacerhein

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Painful osteoarthritis
* Hydarthrosis (synovial effusion)

Exclusion Criteria

* large effusion
* severe pathologies
* anti-osteoarthritic treatments
Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Laboratoires NEGMA

INDUSTRY

Sponsor Role lead

Responsible Party

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Negma-Lerads

Principal Investigators

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Jean-Pierre RAYNAULD, MD

Role: PRINCIPAL_INVESTIGATOR

Institut de Rhumatologie de Montreal

Locations

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Rheumatologic Institut of Montreal

Montreal, Quebec, Canada

Site Status

Countries

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Canada

Other Identifiers

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109196

Identifier Type: -

Identifier Source: secondary_id

HEC/ART06572N

Identifier Type: -

Identifier Source: org_study_id

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