A Safety and Efficacy Evaluation of 3 Bowel Preparations in the Pediatric Population

NCT ID: NCT00425594

Last Updated: 2007-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2007-05-31

Brief Summary

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This randomized, parallel, multi-center, single-blind study is designed to compare the safety and efficacy of 3 bowel preparations in pediatric subjects scheduled to undergo a colonoscopy for a routinely accepted indication.

Detailed Description

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Conditions

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Colonoscopy

Keywords

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colonoscopy bowel preparation prep

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Interventions

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HalfLytely and Bisacodyl Tablets - Formulation 1

Intervention Type DRUG

HalfLytely and Bisacodyl Tablets - Formulation 2

Intervention Type DRUG

NuLYTELY

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female patients who are undergoing colonoscopy for a routinely accepted indication, including:

* Evaluation of BE results
* Endosonography
* Blood in stool
* Anemia of unknown etiology
* Abdominal Pain
* Polypectomy
* Unknown diarrhea or constipation etiology
* Inflammatory bowel disease
* Between 6 and 16 years of age at screening.
* Otherwise in good health, as determined by physical exam and medical history.
* If female, and of child-bearing potential, is using an acceptable form of birth control (hormonal birth control, IUD, double-barrier method, depot contraceptive, sterilized, abstinent, or vasectomized spouse).
* Negative urine pregnancy test at screening, if applicable
* In the investigator's judgment, parent/guardian is mentally competent to provide informed consent to participate in the study.

Exclusion Criteria

* Subjects with known or suspected ileus, gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis, or toxic megacolon
* Subjects impacted at screening
* Subjects with impaired consciousness that predisposes them to pulmonary aspiration.
* Subjects who are undergoing colonoscopy for foreign body removal and decompression
* Subjects with known difficulties for swallowing tablets
* Subjects with pre-existing electrolyte disturbances, such as dehydration, or those secondary to the use of diuretics.
* Subjects who are taking drugs that may affect electrolyte levels with the exception of routine diuretics.
* Subjects with known clinically significant electrolyte abnormalities such as hypernatremia, hyperphosphatemia, hypokalemia, or hypocalcemia
* Subjects who are pregnant or lactating, or intending to become pregnant during the study.
* Subjects of childbearing potential who refuse a pregnancy test.
* Subjects who are allergic to any preparation components
* Subjects who, in the opinion of the investigator, should not be included in the study for any reason, including inability to follow study procedures.
* Subjects who have participated in an investigational clinical, surgical, drug, or device study within the past 30 days.
* Any condition in parent/guardian associated with poor subject compliance (e.g., substance abuse); inability of parent/guardian to return for scheduled visits with their child.
Minimum Eligible Age

6 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Braintree Laboratories

INDUSTRY

Sponsor Role lead

Responsible Party

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Braintree Laboratories, Inc.

Principal Investigators

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John McGowan

Role: STUDY_DIRECTOR

Braintree Laboratories, Inc.

Locations

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Birmingham, Alabama, United States

Site Status

Mobile, Alabama, United States

Site Status

Tuscaloosa, Alabama, United States

Site Status

Phoenix, Arizona, United States

Site Status

Little Rock, Arkansas, United States

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San Francisco, California, United States

Site Status

Gainesville, Florida, United States

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Orlando, Florida, United States

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Park Ridge, Illinois, United States

Site Status

Indianapolis, Indiana, United States

Site Status

Boston, Massachusetts, United States

Site Status

Minneapolis, Minnesota, United States

Site Status

Jackson, Mississippi, United States

Site Status

Omaha, Nebraska, United States

Site Status

Las Vegas, Nevada, United States

Site Status

Morristown, New Jersey, United States

Site Status

Buffalo, New York, United States

Site Status

Cleveland, Ohio, United States

Site Status

Columbus, Ohio, United States

Site Status

Lancaster, Pennsylvania, United States

Site Status

Columbia, South Carolina, United States

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Houston, Texas, United States

Site Status

Temple, Texas, United States

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Salt Lake City, Utah, United States

Site Status

Burlington, Vermont, United States

Site Status

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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F38-25

Identifier Type: -

Identifier Source: org_study_id