VATS Lobectomy for Clinical Stage IB or II Lung Cancer

NCT ID: NCT00425022

Last Updated: 2007-01-30

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-01-31

Brief Summary

To examine the feasibility of VATS lobectomy for clinical stage IB or II non-small cell lung cancer. Success is defined as VATS lobectomy without conversion. If success rate over 90%, VATS lobectomy is considered as feasible procedures for clinical stage IB or II non-small cell lung cancer

Detailed Description

Video-assisted or minimally invasive surgery has become the standard approach for many abdominal surgical operations such as cholecystectomy and fundoplication. With respect to the thorax, video-assisted thoracoscopic surgery(VATS) is the accepted technique for biopsy of the lung and pleura and surgical treatment of pneumothorax.Thoracoscopic, also termed video-assisted thoracoscopic lobectomy has become accepted as a safe and effective procedure to treat early-stage non-small cell lung cancer (NSCLC). Several pilot series of thoracoscopic lobectomy in stage I lung cancer patients have been reported, demonstrating low complication rates and effective short-term and long-term oncologic results. With increasing experience, the indications for thoracoscopic lobectomy have been expanded. Single and Multi-institutional studies have demonstrated that thoracoscopic lobectomy is not only a safe and feasible technique, but is also associated with decreased morbidity, including shorter length of hospitalization and chest tube duration, decreased postoperative pain, improved preservation of pulmonary function, reduced inflammatory response as measured by lower postoperative cytokine levels, and shorter recovery time, as compared with conventional thoracotomy. The advantages of thoracoscopic lobectomy have been demonstrated in patients with clinical stage I NSCLC, and this strategy has been found to be particularly useful for specific subsets of patients such as the elderly and those patients with poor performance status.

The purpose of this study is to know whether VATS lobectomy for clinical stage IB or II non-small cell lung cancer is possible.

Conditions

Carcinoma, Non-Small-Cell Lung; Thoracic Surgery, Video-Assisted

Keywords

lung cancer; video-assisted thoracic surgery

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

thoracoscopy

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Histologic or cytologic diagnosis of non-small cell lung cancer.

2. Clinical stage IB or II, according to the American Joint Committee on Cancer (AJCC).

3. Tumor ≤ 6 cm in size amenable to surgical resection.

4. Including clinical IB or II NSCLC after neoadjuvant therapy

5. Performance status of 0-1 on ECOG scale.

6. At least 18 years old.

7. Patient compliance that allows adequate follow-up.

8. Medical fitness of patients adequate for radical NSCLC surgery.

9. Adequate organ function including the following:Adequate hematologic function: WBC count ³ 4,000/uL, absolute neutrophil count (ANC) ³ 1,500/uL, platelet count ³ 100,000/uL, and hemoglobin ³ 10 gm/dL.Adequate hepatic function: bilirubin £ 1.5 x UNL, ALT or AST £ 2.5 x UNL.Adequate renal function: creatinine £ 1.5mg/dL.

10. Signed informed consent from patient or legal representative.

11. Patients with reproductive potential must use an approved contraceptive method during and for 3 months after the study. Females with childbearing potential must have a negative urine hCG test within 7 days prior to study enrollment.

Exclusion Criteria

1. Metastatic disease in workup

2. Any T3, T4 lesion or N2, N3 lesion

3. Concurrent administration of other tumor therapy, including radiotherapy, immunotherapy except chemotherapy.

4. Active uncontrolled infection.

5. Serious concomitant disorders that would compromise the safety of patient or compromise the patient's ability to tolerate therapy.

6. Significant neurological or mental disorder.

7. Previous history of malignancy in any organ

8. Pregnant or nursing.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Center, Korea

OTHER_GOV

Sponsor Role: lead

Principal Investigators

Hyun-Sung Lee, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

National Cancer Center, Korea

Locations

National Cancer Center

Goyang-si, Gyeonggi-do, South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Hyun-Sung Lee, MD, PhD

Role: CONTACT

Phone: +82-31-920-1648

Email: thoracic@ncc.re.kr

Facility Contacts

Hyun-Sung Lee, MD, PhD

Role: primary

Related Links

http://www.ctsnet.org

Video presentation about complete lymph node dissection under VATS

Other Identifiers

NCCCTS-06-223

Identifier Type: -

Identifier Source: org_study_id