Study to Evaluate a Subcutaneous Four Months Sustained-release Formulation of Triptorelin in Patients With Prostate Cancer

NCT ID: NCT00415246

Last Updated: 2019-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-11-30

Study Completion Date

2007-10-31

Brief Summary

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To identify the proportion of patients remaining medically castrated (testosterone level \< 50 ng/dL) on Day 240 following two administrations of a 4-month sustained-release (SR) formulation of triptorelin.

Detailed Description

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Conditions

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Prostate Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Triptorelin (Decapeptyl®) - Treatment 8 months (pivotal study) followed by a treatment extension of 8 months (extension study)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patient must give written (personally signed and dated) informed consent before completing any study-related procedure, which means any assessment or evaluation that would not have formed part of the normal medical care of the patient
* Patient must be 18 years old or over
* Patient must have a histologically-confirmed diagnosis of locally advanced or metastatic prostate cancer or presenting a relapse after curative treatment which is amenable to androgen deprivation therapy
* Patient must have an estimated survival time of greater than 8 months according to the investigator's assessment

Exclusion Criteria

* Patient at risk of a serious complication in the case of tumour flare (vertebral metastases threatening spinal cord compression or with significant obstructive uropathy)
* Patient who underwent a previous surgical castration
* Prostate cancer therapy within 2 months of baseline visit
* Patient with testosterone level below 150 ng/dL at screening
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Ipsen

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ipsen Medical Director

Role: STUDY_DIRECTOR

Ipsen

Locations

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ULB Erasme

Brussels, , Belgium

Site Status

Academisch Ziekenhuis Vrije Universiteit Brussel

Brussels, , Belgium

Site Status

UCL St Luc

Brussels, , Belgium

Site Status

Universitair Ziekenhuis Antwerpen

Edegem, , Belgium

Site Status

UZ Gasthuisberg

Leuven, , Belgium

Site Status

CHU Hôpital Gabriel Montpied

Clermont-Ferrand, , France

Site Status

Hôpital Claude Huriez

Lille, , France

Site Status

Hôpital Edouard Herriot

Lyon, , France

Site Status

CHU Hôpital Salvator

Marseille, , France

Site Status

Hôtel Dieu

Nantes, , France

Site Status

Hôpital du Val de Grace

Paris, , France

Site Status

Centre Hospitalier Saint Louis

Paris, , France

Site Status

Hôpital Cochin

Paris, , France

Site Status

Hôpital Bichat

Paris, , France

Site Status

CHU Hôpital de la Miletrie

Poitiers, , France

Site Status

Hôpital Pontchaillou

Rennes, , France

Site Status

CHU Rangueil

Toulouse, , France

Site Status

Olega Hublarova arsta prakse urologija

Daugavpils, , Latvia

Site Status

Latvijas Onkologijas centre

Riga, , Latvia

Site Status

Paula Stradina Kliniska Universitates slimnica

Riga, , Latvia

Site Status

Kauno Medicinos Universitteto Klinikos

Kaunas, , Lithuania

Site Status

UAB 'Vilniaus onkourologijos-ginekologijos klinika

Vilnius, , Lithuania

Site Status

Vilniaus universiteto

Vilnius, , Lithuania

Site Status

Swietokrzyskie Centrum Onkologii

Kielce, , Poland

Site Status

NZOZ Specjalista Sp, z.o.o.

Kutno, , Poland

Site Status

Centrum Onkologii Instytut im. M. Sklodowskiej-Curie

Warsaw, , Poland

Site Status

Akademicki Szpital Kliniczny

Wroclaw, , Poland

Site Status

Hospital Gregorio Maranon

Madrid, , Spain

Site Status

Ivano Frankovsk State Medical University

Ivano-Frankivsk, , Ukraine

Site Status

Scientific Research Institute of Urology

Kiev, , Ukraine

Site Status

Aberdeen Royal Infirmary

Aberdeen, , United Kingdom

Site Status

Countries

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Belgium France Latvia Lithuania Poland Spain Ukraine United Kingdom

Other Identifiers

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2006-001511-30

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

2-55-52014-145

Identifier Type: -

Identifier Source: org_study_id

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