Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
48 participants
INTERVENTIONAL
2006-11-30
2007-12-31
Brief Summary
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The inflammatory response to endotoxin injection and the insulin-sensitivity is examined before and after four weeks ingestion of probiotics.
Detailed Description
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In this study type 2 diabetics (N=24) and healthy control (N=24) are given the probiotic bacteria Lactobacillus Acidophilus NCFM for four weeks. The anti-inflammatory effect is examined by evaluating the inflammatory response (White blood cell count, plasma-cytokines) to an iv injection of endotoxin (0,3 ng/kg) before and after the intervention. Also the insulin-sensitivity is measured with an hyperinsulinemic euglycemic clamp before and after L. acidophilus NCFM.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Interventions
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Lactobacillus acidophilus NCFM
Eligibility Criteria
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Inclusion Criteria
* Type 2 diabetes
Exclusion Criteria
* Lung disease
* Infections in the last two weeks before endotoxin injections.
* Treatment with antibiotics
25 Years
80 Years
MALE
Yes
Sponsors
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Royal Veterinary and Agricultural University, Denmark
OTHER
Rigshospitalet, Denmark
OTHER
Principal Investigators
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Anne Sofie Andreasen, MD
Role: PRINCIPAL_INVESTIGATOR
Rigshospitalet, Denmark
Locations
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Center of Inflammation and metabolism 7641 and Intensive Care Unit 4131, Rigshospitalet
Copenhagen, , Denmark
Countries
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Central Contacts
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Other Identifiers
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probiotics.sa.cim.rh.dk
Identifier Type: -
Identifier Source: org_study_id