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Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)

NCT ID: NCT00408824

Last Updated: 2007-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

4000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-09-30

Brief Summary

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The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance. The alteration of the secretion of adipocytokines from accumulated visceral adipose tissue in the obese induces insulin resistance. The purpose of this study is to identify gene polymorphisms that confer susceptibility to the metabolic syndrome and to make up a new health guidance program based on genetic risk assessment. About 25% of male employees over 45 years old in a certain company are diagnosed with the metabolic syndrome in medical examination. We, the researchers at Nagoya University, will analyze gene polymorphism and various biomarkers of over 3500 company employees.

Detailed Description

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Conditions

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Healthy Metabolic Syndrome X Hyperlipidemia Hypertension Diabetes Mellitus

Keywords

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insulin resistance adipocytokine Metabolic syndrome Diabetes

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects who work for a certain company
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nagoya University

OTHER

Sponsor Role lead

Principal Investigators

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Kenji Yasui, MD, PhD

Role: STUDY_CHAIR

Department of Bio-information Analysis, Research Institute of Environmental Medicine, Nagoya University

Locations

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Department of Bio-information Analysis, Research Institute of Environmental Medicine, Nagoya University

Nagoya, Aichi-ken, Japan

Site Status RECRUITING

Countries

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Japan

Central Contacts

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Kenji Yasui, MD, PhD

Role: CONTACT

Phone: +81-52-788-6211

Email: [email protected]

Facility Contacts

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Kenji Yasui, MD, PhD

Role: primary

References

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Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8.

Reference Type DERIVED
PMID: 21150884 (View on PubMed)

Other Identifiers

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RIEM-G-3

Identifier Type: -

Identifier Source: org_study_id