Retinal Blood Flow and Microthrombi in Type 1 Diabetes

NCT ID: NCT00406991

Last Updated: 2015-10-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2003-06-30
• Study Completion Date: 2006-03-31

Brief Summary

The project aims to find mechanisms for the abnormal retinal blood flow that in diabetic patients often precedes any evidence of clinical retinopathy and may contribute to the development of retinopathy.

Specifically, the projects tests the hypothesis that reduced retinal blood flow found in young patients with type 1 diabetes reflects increased resistance in the small vessels of the retina caused by the formation of small blood clots, called microthrombi; and that antiplatelet agents normalize the reduced retinal blood flow.

Detailed Description

The ultimate goal of this research is to contribute to the development of strategies to prevent diabetic retinopathy. This project will test the hypothesis that antiplatelet agents normalize the reduced blood flow observed early in the course of type 1 diabetes. If the hypothesis is proven correct, the results will indicate that the formation of small blood clots (microthrombi) occurs early in diabetic retinal vessels. In turn, because microthrombosis could readily account for the occlusive microangiopathy that causes the sight-threatening stages of diabetic retinopathy, the results will propose the desirability of antiplatelet therapy for the prevention of diabetic retinopathy.

We have three specific aims:

1. To confirm that, under basal conditions, retinal blood flow measured with the laser Doppler method in a group of type 1 diabetic patients with no or minimal retinopathy differs from the flow measured in age- and sex-matched nondiabetic control subjects;

2. To determine whether the response of retinal blood flow to low-dose aspirin (81 mg/day) administered for 2 months versus placebo, differs between type 1 diabetic patients with no or minimal retinopathy and age- and sex-matched nondiabetic control subjects;

3. To determine whether in type 1 diabetic patients with no or minimal retinopathy the response of retinal blood flow to low-dose aspirin differs from the response to clopidogrel, a drug that interferes with platelet function downstream of the site of aspirin action.

Conditions

Diabetes; Diabetic Retinopathy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: DOUBLE

Interventions

aspirin

Intervention Type: DRUG

clopidogrel

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age 18-45 years,
• type 1 diabetes duration 1-15 years,
• absent or minimal retinopathy (EDTRS 20).
• Age- and gender-matched healthy controls

Exclusion Criteria

• smoking,
• systemic diseases other than diabetes,
• retinal diseases other than diabetic retinopathy,
• pregnancy,
• bleeding disorders,
• aspirin allergy,
• use of anti-platelet agents,
• non-steroidal anti-inflammatory agents,
• angiotensin converting enzyme inhibitors,
• angiotensin receptor antagonists,
• Vitamin E in large doses.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Schepens Eye Research Institute

OTHER

Sponsor Role: lead

Principal Investigators

Mara Lorenzi, MD

Role: PRINCIPAL_INVESTIGATOR

Schepens Eye Research Institute

Locations

Schepens Eye Research Institute

Boston, Massachusetts, United States

Countries

United States

Other Identifiers

2003P-000224

Identifier Type: -

Identifier Source: secondary_id

EY014812

Identifier Type: -

Identifier Source: secondary_id

2002-015

Identifier Type: -

Identifier Source: org_study_id