Evaluation of Efficacy and Safety of Lovaza (Omega-3-Acid Ethyl Esters) in Recurrent, Symptomatic Atrial Fibrillation

NCT ID: NCT00402363

Last Updated: 2017-01-30

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

663 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-11-30

Study Completion Date

2010-01-31

Brief Summary

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The purpose of this study is to evaluate efficacy and safety of Omacor (omega-3-acid ethyl esters) in patients with recurrent, symptomatic atrial fibrillation.

Detailed Description

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Conditions

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Fibrillation, Atrial

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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omega-3-acid ethyl esters

Group Type EXPERIMENTAL

omega-3-acid ethyl esters

Intervention Type DRUG

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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omega-3-acid ethyl esters

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Men and women age 18 years or older
* History of symptomatic atrial fibrillation (either paroxysmal or persistent)
* Provide written informed consent and authorization for protected health information disclosure

Exclusion Criteria

* Permanent (chronic) atrial fibrillation
* Antiarrhythmic drug therapy which cannot be stopped
* Use of amiodarone with prior 6 months
* History of unsuccessful cardioversion
* History of certain cardiovascular conditions or cardiac surgery within prior 6 months
* History of stroke within prior 6 months
* Implanted cardio-defibrillator
* Certain circulatory, thyroid, pulmonary, liver, kidney, musculoskeletal or metabolic conditions, or cancer (except non-melanoma skin cancer)
* Poorly controlled diabetes
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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Birmingham, Alabama, United States

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Huntsville, Alabama, United States

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Anchorage, Alaska, United States

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Cottonwood, Arizona, United States

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Mesa, Arizona, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Fort Smith, Arkansas, United States

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Hot Springs, Arkansas, United States

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Alamada, California, United States

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Bakersfield, California, United States

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Bakersfield, California, United States

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Beverly Hills, California, United States

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Carmichael, California, United States

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Fair Oaks, California, United States

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Fountain Valley, California, United States

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Loma Linda, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Merced, California, United States

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Palm Springs, California, United States

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Poway, California, United States

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Redondo Beach, California, United States

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Sacramento, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Diego, California, United States

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Vista, California, United States

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Walnut Creek, California, United States

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Aurora, Colorado, United States

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Colorado Springs, Colorado, United States

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Littleton, Colorado, United States

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Bridgeport, Connecticut, United States

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Farmington, Connecticut, United States

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Guilford, Connecticut, United States

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Washington D.C., District of Columbia, United States

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Washington D.C., District of Columbia, United States

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Aventura, Florida, United States

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Bay Pines, Florida, United States

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Daytona Beach, Florida, United States

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Delray Beach, Florida, United States

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Fort Meyers, Florida, United States

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Gainesville, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Orlando, Florida, United States

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Pinellas Park, Florida, United States

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Atlanta, Georgia, United States

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Atlanta, Georgia, United States

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Decatur, Georgia, United States

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Tucker, Georgia, United States

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Bannockburn, Illinois, United States

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Gurnee, Illinois, United States

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Normal, Illinois, United States

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Louisville, Kentucky, United States

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Covington, Louisiana, United States

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Lacombe, Louisiana, United States

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Auburn, Maine, United States

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Annapolis, Maryland, United States

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Ayer, Massachusetts, United States

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Brookline, Massachusetts, United States

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Worcester, Massachusetts, United States

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Alpena, Michigan, United States

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Cadillac, Michigan, United States

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Detroit, Michigan, United States

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Lansing, Michigan, United States

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Mineappolis, Minnesota, United States

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Rochester Hills, Minnesota, United States

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Saint Paul, Minnesota, United States

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Gulfport, Mississippi, United States

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Billings, Montana, United States

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Kalispell, Montana, United States

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Babylon, New York, United States

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Mineola, New York, United States

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Troy, New York, United States

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West Islip, New York, United States

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Charlotte, North Carolina, United States

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Charlotte, North Carolina, United States

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Hickory, North Carolina, United States

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Bryan, Ohio, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Fairview Park, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Beaver, Pennsylvania, United States

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Greensburg, Pennsylvania, United States

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Hershey, Pennsylvania, United States

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Langhorne, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Ridley Park, Pennsylvania, United States

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West Chester, Pennsylvania, United States

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Wynnewood, Pennsylvania, United States

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Wyomissing, Pennsylvania, United States

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Cranston, Rhode Island, United States

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Pawtucket, Rhode Island, United States

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Westerly, Rhode Island, United States

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Greer, South Carolina, United States

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Spartanburg, South Carolina, United States

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Sioux Falls, South Dakota, United States

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Jackson, Tennessee, United States

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Memphis, Tennessee, United States

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Austin, Texas, United States

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Beaumont, Texas, United States

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Corpus Christi, Texas, United States

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Humble, Texas, United States

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Lubbock, Texas, United States

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McKinney, Texas, United States

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Odessa, Texas, United States

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Orange, Texas, United States

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Tyler, Texas, United States

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Arlington, Virginia, United States

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Chesapeake, Virginia, United States

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Galax, Virginia, United States

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Richlands, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Springfield, Virginia, United States

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Burien, Washington, United States

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Huntington, West Virginia, United States

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Beloit, Wisconsin, United States

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Madison, Wisconsin, United States

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Marshfield, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Wausau, Wisconsin, United States

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Countries

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United States

References

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Kowey PR, Reiffel JA, Ellenbogen KA, Naccarelli GV, Pratt CM. Efficacy and safety of prescription omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: a randomized controlled trial. JAMA. 2010 Dec 1;304(21):2363-72. doi: 10.1001/jama.2010.1735. Epub 2010 Nov 15.

Reference Type RESULT
PMID: 21078810 (View on PubMed)

Pratt CM, Reiffel JA, Ellenbogen KA, Naccarelli GV, Kowey PR. Efficacy and safety of prescription omega-3-acid ethyl esters for the prevention of recurrent symptomatic atrial fibrillation: a prospective study. Am Heart J. 2009 Aug;158(2):163-169.e1-3. doi: 10.1016/j.ahj.2009.05.024.

Reference Type DERIVED
PMID: 19619690 (View on PubMed)

Study Documents

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Document Type: Informed Consent Form

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Individual Participant Data Set

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Annotated Case Report Form

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Dataset Specification

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Study Protocol

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Statistical Analysis Plan

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Clinical Study Report

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Related Links

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https://www.clinicalstudydatarequest.com

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Other Identifiers

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OM8 Afib

Identifier Type: -

Identifier Source: org_study_id

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