Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1000 participants
OBSERVATIONAL
2006-01-15
2030-12-31
Brief Summary
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In this study, the investigators are collecting genetic material via blood or saliva and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS. The investigators are enrolling inviduals with IC/BPS and their family members (family members with and without IC like symptoms). Travel to Boston not required.
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Detailed Description
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Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Study Groups
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1 cohort
All participants will undergo genome sequencing and urinalysis studies.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Males and females of any age
* Urinary frequency - more than 1X/hour, and/or
* Dysuria, and/or
* Pelvic, suprapubic, or abdominal pain - for 3 months or longer
* Nocturia
* Normal urinary stream (by history)
* No evidence of active bacterial UTI (no pyuria \& negative urinary culture for last 3 months)
* First degree relative of someone with above symptoms
Exclusion Criteria
* Underlying inborn conditions affecting the urinary tract
* Surgery/chemotherapy affected pelvic area
* GI or GU cancers
* Severe Constipation in children only
1 Year
ALL
No
Sponsors
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Boston Children's Hospital
OTHER
Responsible Party
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Catherine Brownstein
Assistant Professor of Genetics and Pediatrics, Harvard Medical School
Principal Investigators
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Catherine Brownstein, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Boston Children's Hosptial
Locations
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Boston Children's Hospital (BCH)
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Dimitrakov JD. A case of familial clustering of interstitial cystitis and chronic pelvic pain syndrome. Urology. 2001 Aug;58(2):281. doi: 10.1016/s0090-4295(01)01138-4.
Estrella E, Rockowitz S, Thorne M, Smith P, Petit J, Zehnder V, Yu RN, Bauer S, Berde C, Agrawal PB, Beggs AH, Gharavi AG, Kunkel L, Brownstein CA. Mendelian Disorders in an Interstitial Cystitis/Bladder Pain Syndrome Cohort. Adv Genet (Hoboken). 2022 Nov 27;4(1):2200013. doi: 10.1002/ggn2.202200013. eCollection 2023 Mar.
Other Identifiers
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91208
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
04-11-160
Identifier Type: -
Identifier Source: org_study_id
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