Study Evaluating Safety & Immunogenicity of rLP2086 Vaccine in Adolescents

NCT ID: NCT00387725

Last Updated: 2014-11-21

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

127 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-11-30

Study Completion Date

2008-02-29

Brief Summary

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Study to evaluate the safety of an investigational meningitis vaccine and the immune response to it in adolescents

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Group A

20ug Experimental

Group Type EXPERIMENTAL

rLP2086

Intervention Type BIOLOGICAL

Vaccine administered at 0, 1, and 6 months

Group 2

60ug Experimental

Group Type EXPERIMENTAL

rLP2086

Intervention Type BIOLOGICAL

Vaccine administered at 0, 1, and 6 months

Group 3

200ug Experimental

Group Type EXPERIMENTAL

rLP2086

Intervention Type BIOLOGICAL

Vaccine administered at 0, 1, and 6 months

Group 4

Active comparator

Group Type ACTIVE_COMPARATOR

rLP2086

Intervention Type BIOLOGICAL

Vaccine administered at 0, 1, and 6 months

Interventions

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rLP2086

Vaccine administered at 0, 1, and 6 months

Intervention Type BIOLOGICAL

rLP2086

Vaccine administered at 0, 1, and 6 months

Intervention Type BIOLOGICAL

rLP2086

Vaccine administered at 0, 1, and 6 months

Intervention Type BIOLOGICAL

rLP2086

Vaccine administered at 0, 1, and 6 months

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Aged 8 to 14 years at the time of enrollment.
* Healthy male or female subjects
* Negative urine pregnancy test for female subjects

Exclusion Criteria

* Prior vaccination with a meningococcal B vaccine
* Prior meningococcal disease
Minimum Eligible Age

8 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Sydney Children's Hospital

Randwick, New South Wales, Australia

Site Status

The Children's Hospital at Westmead

Westmead, New South Wales, Australia

Site Status

Royal Children's Hospital

Herston, Queensland, Australia

Site Status

Princess Margaret Hospital for Children

Subiaco, Western Australia, Australia

Site Status

Sir Albert Sakzewski Virus Research Centre (SASVRC)

Herston, , Australia

Site Status

Women's & Children's Hospital

North Adelaide, , Australia

Site Status

The Telethon Institute for Child Health Research

Subiaco, , Australia

Site Status

National Centre for Immunisation

Westmead, , Australia

Site Status

Department of Paediatrics and Child Health

Woden, , Australia

Site Status

Countries

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Australia

Related Links

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Other Identifiers

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B1971006

Identifier Type: OTHER

Identifier Source: secondary_id

6108A1-501

Identifier Type: -

Identifier Source: org_study_id