Metabolic Study of Concentric and Eccentric Muscle Training

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-04-30

Study Completion Date

2003-08-31

Brief Summary

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The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Detailed Description

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Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

Conditions

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Lipid Metabolism Insulin Resistance Inflammation

Keywords

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exercise lipid metabolism lipoproteins insulin resistance inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

ECT

Blinding Strategy

NONE

Interventions

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physical training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* healthy men and women
* age over 30 years

Exclusion Criteria

* previous systematic endurance training (≥3 times per week ≥30 min)
* body mass index \>30 kg/m2
* heavy smoking (\>20 cigarettes per day)
* regular alcohol consumption \>60g per day
* established musculoskeletal disease
* history of cardiovascular disease
* diabetes mellitus
* unwillingness to stay in the area for the whole study period

Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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Heinz Drexel, MD

Role: PRINCIPAL_INVESTIGATOR

Vorarlberg Institut of Vascular Investigation and Treatment, Academic Teaching Hospital, Austria

Locations

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Vorarlberg Institute of Vascular Investigation and Treatment

Feldkirch, Vorarlberg, Austria

Site Status

Countries

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Austria

References

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Drexel H, Mader A, Saely CH, Tautermann G, Dopheide JF, Vonbank A. Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance. Sci Rep. 2021 Jul 15;11(1):14503. doi: 10.1038/s41598-021-93879-1.

Reference Type DERIVED

PMID: 34267272 (View on PubMed)

Other Identifiers

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K01-2003-1

Identifier Type: -

Identifier Source: org_study_id