Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
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COMPLETED
PHASE2
138 participants
INTERVENTIONAL
2006-09-30
2011-02-28
Brief Summary
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Detailed Description
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This study is designed to examine how supplementation with omega-3 polyunsaturated fatty acids (key fish oil components) affects aspects of your immune response, and your mood; because some research suggests that people who eat more fish may do better during stressful times, the study will also examine how fish oil affects your immune response to stress, certain stress hormone responses, and your psychological response to stress.
For detailed information about the study, please visit our website at http://www.stressandhealth.org
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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1
1.25 g/d
Omega 3 (Fish Oil) Supplementation
1.25 g or 2.496 g daily for 4 months
2
2.496 g/d
Omega 3 (Fish Oil) Supplementation
1.25 g or 2.496 g daily for 4 months
3
Placebo
matching placebo capsule daily for 4 months
Interventions
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Omega 3 (Fish Oil) Supplementation
1.25 g or 2.496 g daily for 4 months
Placebo
matching placebo capsule daily for 4 months
Eligibility Criteria
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Inclusion Criteria
* NOT currently taking any sort of fish oil or omega 3 supplement
Exclusion Criteria
* Certain lifestyle habits such as smoking or exercising vigorously for 2 or more hours a week may also exclude applicants from participating
40 Years
88 Years
ALL
Yes
Sponsors
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National Institute on Aging (NIA)
NIH
Ohio State University
OTHER
Responsible Party
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Janice Kiecolt-Glaser
Professor of Psychiatry and Psychology
Principal Investigators
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Janice K. Kiecolt-Glaser
Role: PRINCIPAL_INVESTIGATOR
Ohio State University
Locations
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The Ohio State University
Columbus, Ohio, United States
Countries
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References
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Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser R. Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial. Brain Behav Immun. 2012 Aug;26(6):988-95. doi: 10.1016/j.bbi.2012.05.011. Epub 2012 May 26.
Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun. 2013 Feb;28:16-24. doi: 10.1016/j.bbi.2012.09.004. Epub 2012 Sep 23.
Madison AA, Belury MA, Andridge R, Renna ME, Rosie Shrout M, Malarkey WB, Lin J, Epel ES, Kiecolt-Glaser JK. Omega-3 supplementation and stress reactivity of cellular aging biomarkers: an ancillary substudy of a randomized, controlled trial in midlife adults. Mol Psychiatry. 2021 Jul;26(7):3034-3042. doi: 10.1038/s41380-021-01077-2. Epub 2021 Apr 20.
Jaremka LM, Derry HM, Bornstein R, Prakash RS, Peng J, Belury MA, Andridge RR, Malarkey WB, Kiecolt-Glaser JK. Omega-3 supplementation and loneliness-related memory problems: secondary analyses of a randomized controlled trial. Psychosom Med. 2014 Oct;76(8):650-8. doi: 10.1097/PSY.0000000000000104.
Related Links
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Please click here to visit our website if you would like to read more about the study or apply to participate.
Other Identifiers
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2006H0054
Identifier Type: -
Identifier Source: secondary_id
AG0087
Identifier Type: -
Identifier Source: org_study_id