Long-Term Efficacy in AMD of Rheopheresis in North America

NCT ID: NCT00380172

Last Updated: 2006-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-10-31

Study Completion Date

2007-10-31

Brief Summary

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The purpose of these studies are to evaluate the effect on vision in subjects with AMD who received active and placebo treatment in the MIRA-1 study.

Detailed Description

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Conditions

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Macular Degeneration

Keywords

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AMD Macular Degeneration Retinal Degeneration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Rheopheresis blood filtration

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Must have participated in treatment arm of MIRA-1 trial and completed 4 treatments and 6 and 9 month follow up visits.
* Dry AMD in at least one eye.
* Available for study duration of 12 months.
* Weigh \>110 lbs.
* If on lipid-lowering medication must remain on for duration of trial. If not, must agree to not initate during trial.
* Normal Pt/ PTT. If on coumadin, at the discretion of the investigator.
* Must be highly motivated, alert and oriented, and able to provide consent.
* Agree to discontinue current ocular vitamin regimen and take uniform supplement provided by the sponsor.

Exclusion Criteria

* Both eyes wet AMD.
* Condition limiting view of the fundus.
* Poor general health or unstable diseases.
* HCT \< 35%, evidence of active bleeding, platelet count \<100000 K/uL, prolonged Pt/ PTT, or significant coagupapathies.
* significant cardiac problems.
* Uncontrolled hypertension.
* History of CVA of TIA within a year.
* Significant hepatic, renal, or pulmonary disease, or insulin dependent diabetes.
* Allergy to fluorescein sodium and indocyanine green (ICG), heparin, ACDA, local anesthetics, or adhesive tape.
* Pregnant or breastfeeding women, or women of childbearing potential not using chemical or mechanical contraception.
* Investigation trial within 30 days.
* Major surgery within 30 days.
* Unwilling to adhere to visit schedule.
* Unstable medical of psychological condition.
Minimum Eligible Age

0 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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OccuLogix

INDUSTRY

Sponsor Role lead

Principal Investigators

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Nozhat Choudry', Ph.D.

Role: STUDY_DIRECTOR

OccuLogix, Inc.

Locations

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Retina Vitreous Associates

Beverly Hills, California, United States

Site Status

Aran Eye Associates

Coral Gables, Florida, United States

Site Status

Retina Health Care

Fort Myers, Florida, United States

Site Status

The Macula Center

Palm Harbor, Florida, United States

Site Status

UIC Eye Center

Chicago, Illinois, United States

Site Status

Macula Care

New York, New York, United States

Site Status

Carolina Eye Associates

Southern Pines, North Carolina, United States

Site Status

Associated Retinal Consultants

Bala-Cynwyd, Pennsylvania, United States

Site Status

W. Bradley Kates, MD

Oakville, Ontario, Canada

Site Status

Countries

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United States Canada

Other Identifiers

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AMD-03-02

Identifier Type: -

Identifier Source: org_study_id