An Open-Label Study of YM087 (Conivaptan) in Patients With Euvolemic or Hypervolemic Hyponatremia

NCT ID: NCT00379847

Last Updated: 2014-05-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

251 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-02-29

Study Completion Date

2005-06-30

Brief Summary

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This study will investigate the application of a vasopressin antagonist in the treatment of hyponatremia most likely caused by inappropriate AVP secretion. The population studied will include patients with euvolemic or hypervolemic hyponatremia.

Detailed Description

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Conditions

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Hyponatremia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Lower dose

Group Type EXPERIMENTAL

conivaptan

Intervention Type DRUG

IV

2

Higher dose

Group Type EXPERIMENTAL

conivaptan

Intervention Type DRUG

IV

Interventions

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conivaptan

IV

Intervention Type DRUG

Other Intervention Names

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Vaprisol YM087

Eligibility Criteria

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Inclusion Criteria

* Serum sodium levels less than or equal 130mEq/L
* Euvolemic or Hypervolemic hyponatremia

Exclusion Criteria

* Clinical evidence of volume depletion or dehydration
* Untreated severe hypothyroidism, hyperthyroidism, or adrenal insufficiency
* Uncontrolled brady-or tachyarrhythmias requiring pacemaker placement or treatment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cumberland Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Astellas Pharma US, Inc.

Principal Investigators

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Art Wheeler, MD

Role: STUDY_DIRECTOR

Cumberland Pharmaceuticals, Inc.

Locations

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Tuscon, Arizona, United States

Site Status

Denver, Colorado, United States

Site Status

Washington D.C., District of Columbia, United States

Site Status

Augusta, Georgia, United States

Site Status

Petoskey, Michigan, United States

Site Status

Cincinnati, Ohio, United States

Site Status

Columbia, South Carolina, United States

Site Status

Afula, , Israel

Site Status

Ashkelon, , Israel

Site Status

Hadera, , Israel

Site Status

2 Sites

Haifa, , Israel

Site Status

Holon, , Israel

Site Status

2 Sites

Jerusalem, , Israel

Site Status

Nahariya, , Israel

Site Status

Rehovot, , Israel

Site Status

2 Sites

Safed, , Israel

Site Status

Tel Aviv, , Israel

Site Status

Ẕerifin, , Israel

Site Status

Amanzimototi, , South Africa

Site Status

Bellville, , South Africa

Site Status

Bloemfontein, , South Africa

Site Status

2 Sites

Durban, , South Africa

Site Status

4 Sites

Johannesburg, , South Africa

Site Status

Krugersdorp, , South Africa

Site Status

Lyttelton, , South Africa

Site Status

Pretoria, , South Africa

Site Status

Somerset West, , South Africa

Site Status

Soweto, , South Africa

Site Status

Countries

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United States Israel South Africa

Other Identifiers

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087-CL-080

Identifier Type: -

Identifier Source: org_study_id

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