Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma

NCT ID: NCT00379080

Last Updated: 2017-04-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-01-31
• Study Completion Date: 2013-06-30

Brief Summary

This phase I/II trial is studying the side effects and best dose of tandutinib and to see how well it works in treating patients with recurrent or progressive glioblastoma.Tandutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Detailed Description

PRIMARY OBJECTIVES:

I. Assess the ability of tandutinib to achieve a target tumor/plasma ratio ≥ 0.33 in patients with recurrent glioblastoma undergoing resection. (Feasibility study) II. Detect potential biological effects of tandutinib by measuring platelet-derived growth factor receptor phosphorylation status and downstream activation of Akt and Erk. (Feasibility study) III. Determine the maximum tolerated dose of tandutinib in patients with recurrent or progressive glioblastoma. (Phase I) IV. Estimate the frequency of toxicities associated with tandutinib in patients with recurrent or progressive glioblastoma. (Phase I) V. Describe the pharmacokinetics of this route of administration in patients with recurrent or progressive glioblastoma. (Phase I) VI. Assess tumor response rate in patients with recurrent or progressive glioblastoma. (Phase II)

SECONDARY OBJECTIVES:

I. Estimate overall survival of patients with recurrent or progressive glioblastoma. (Phase II) II. Estimate the 6-month progression-free survival rate in these patients. (Phase II) III. Assess the toxicities associated with tandutinib in these patients. (Phase II) IV. Assess the pharmacokinetic profile of this route of administration in these patients. (Phase II) V. Explore protein-expression patterns that distinguish patients who respond to therapy from those who do not. (Phase II)

OUTLINE: This is a multicenter, prospective, nonrandomized, feasibility study and phase I study (in parallel) followed by an open label phase II study.

FEASIBILITY STUDY: Patients receive oral tandutinib twice daily for 7 days. Patients then undergo biopsy or surgery to remove the tumor. Within 2 weeks after biopsy or surgery, patients receive oral tandutinib twice daily* on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

PHASE I: Patients receive oral tandutinib twice daily* on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of tandutinib until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. At least 6 patients are treated at the MTD.

[Note: *On day 1 of course 1, patients receive only 1 dose of tandutinib.]

PHASE II: Patients receive tandutinib as in phase I at the MTD determined in phase I.

Patients undergo blood sample collection for pharmacokinetic studies. Patients in the feasibility portion of the study also undergo blood and tissue sample collection for correlative studies by mass spectrometry for tandutinib concentration. Samples are also examined for circulating endothelial cells and plasma proteins (vascular endothelial growth factor [VEGF]-A, -B, -C, and -D, soluble VEGF receptors [sVEGFR's], placental growth factor [P1GF], platelet-derived growth factor [PDGF]-AA, PDGF-AB, PDGF-BB, angiopoietin-1 and -2, tumstatin, thrombospondin-1, and IL-8) as potential markers of the antiangiogenic effect of tandutinib.

After completion of study treatment, patients are followed every 2 months.

Conditions

Adult Brain Tumor; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Arm I - Feasibility

Patients receive oral tandutinib twice daily for 7 days. Patients then undergo biopsy or surgery to remove the tumor. Within 2 weeks after biopsy or surgery, patients receive oral tandutinib twice daily* on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

conventional surgery

oral tandutinib

Pharmacological study

Tissue samples

Group Type: EXPERIMENTAL

conventional surgery

Intervention Type: PROCEDURE

Undergo surgery

tandutinib

Intervention Type: DRUG

Given orally

pharmacological study

Intervention Type: OTHER

Correlative studies

Tissue samples

Intervention Type: OTHER

Correlative studies

Arm 2 - Dose Escalation (Phase 1)

Phase I: Patients receive oral tandutinib twice daily* on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of tandutinib until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. At least 6 patients are treated at the MTD.

the starting dose for tandtinib is 500mg BID

oral tandutinib

Pharmacological study

Tissue samples

Group Type: EXPERIMENTAL

tandutinib

Intervention Type: DRUG

Given orally

pharmacological study

Intervention Type: OTHER

Correlative studies

Tissue samples

Intervention Type: OTHER

Correlative studies

Arm 3 - Phase 2

Patients receive tandutinib as in phase I at the MTD determined in phase I.

600mg was the determined MTD in Dose Escalation

oral tandutinib

Pharmacological study

Tissue samples

Group Type: EXPERIMENTAL

tandutinib

Intervention Type: DRUG

Given orally

pharmacological study

Intervention Type: OTHER

Correlative studies

Tissue samples

Intervention Type: OTHER

Correlative studies

Interventions

conventional surgery

Undergo surgery

Intervention Type: PROCEDURE

tandutinib

Given orally

Intervention Type: DRUG

pharmacological study

Correlative studies

Intervention Type: OTHER

Tissue samples

Correlative studies

Intervention Type: OTHER

Other Intervention Names

MLN518; CT53518

Eligibility Criteria

Inclusion Criteria

• Measurable disease, defined as contrast-enhancing progressive or recurrent glioblastoma by MRI or CT imaging within the past 2 weeks
• Must be maintained on a stable corticosteroid regimen from the time of baseline scan to the start of study treatment
• Feasibility study only:

• Planning to undergo surgical resection or biopsy
• Stereotactic biopsy for confirmation of tumor progression or differentiation of tumor progression from treatment-induced effects allowed
• Corticosteroids must be tapered to the lowest required steroid dose and patient must be maintained on a stable dose after surgery or biopsy
• Karnofsky performance status 60-100%
• Absolute neutrophil count >= 1,500/mm^3
• Hemoglobin >= 10 mg/dL
• Bilirubin =< 1.5 mg/dL
• AST and ALT =< 4 times upper limit of normal
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier method contraception during and for 3 months after completion of study treatment
• Mini Mental State Exam score >= 15
• Mean QTc =< 500 msec (with Bazett's correction) by screening electrocardiogram
• LVEF >= 40%
• No history of familial long QT syndrome
• No myocardial infarction within the past 6 months
• No severe uncontrolled ventricular arrhythmias
• No uncontrolled angina
• No electrocardiographic evidence of acute ischemia or active conduction system abnormalities
• No ongoing vomiting or nausea >= grade 2
• No gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for intravenous alimentation
• No active peptic ulcer disease
• No other condition that would impair ability to swallow pills or absorb oral medications
• No muscular dystrophy
• No myasthenia gravis
• No other known or suspected primary muscular or neuromuscular disease
• No history of allergic reactions attributed to compounds of similar chemical or biologic composition to tandutinib (e.g., erlotinib hydrochloride, gefetinib, or doxazosin mesylate)
• Patients who developed an acneiform/maculopustular rash while receiving either gefitinib or erlotinib hydrochloride are eligible unless the rash is considered an allergic reaction (angioedema/urticaria) or Stevens-Johnson syndrome
• No ongoing or active infections
• No psychiatric illness or social situations that would preclude study compliance
• No other serious infection or medical illness
• At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas)
• No other uncontrolled illness
• No other malignancy within the past 5 years except for basal cell or squamous cell skin cancer or carcinoma in situ of the cervix or breast
• Recovered from prior therapy
• At least 3 months since prior radiotherapy
• No prior surgical procedures affecting absorption
• No concurrent combination antiretroviral therapy for HIV-positive patients
• No other concurrent investigational agents
• No concurrent agent that would cause QTc prolongation
• No concurrent prophylactic growth factors (e.g., filgrastim [G-CSF] or sargramostim [GM-CSF])
• At least 10 days since prior and no concurrent anticonvulsant drugs that induce hepatic metabolic enzymes (e.g., primidone, oxcarbazepine, phenytoin, carbamazepine, or phenobarbital)
• No prior treatment with small molecule inhibitors of platelet-derived growth factor receptor (e.g., sunitinib malate, sorafenib, or imatinib mesylate)
• Platelet count >= 100,000/mm^3
• No New York Heart Association class III or IV heart failure
• Creatinine =< 1.5 mg/dL OR creatinine clearance >= 60mL/min

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Tracy Batchelor, MD

Role: PRINCIPAL_INVESTIGATOR

National Cancer Institute (NCI)

Locations

University of Alabama at Birmingham

Birmingham, Alabama, United States

H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, United States

Emory University

Atlanta, Georgia, United States

Johns Hopkins University

Baltimore, Maryland, United States

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Henry Ford Hospital

Detroit, Michigan, United States

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Countries

United States

Other Identifiers

NCI-2009-00681

Identifier Type: REGISTRY

Identifier Source: secondary_id

CDR0000495253

Identifier Type: -

Identifier Source: secondary_id

NABTT 0504

Identifier Type: OTHER

Identifier Source: secondary_id

NABTT-0504

Identifier Type: OTHER

Identifier Source: secondary_id

U01CA137443

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCI-2009-00681

Identifier Type: -

Identifier Source: org_study_id