European Registry on STEMI Patients Transferred for PCI With Upstream Use of Abciximab - EuroTransfer Registry

NCT ID: NCT00378391

Last Updated: 2007-06-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-11-30

Study Completion Date

2007-02-28

Brief Summary

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EUROTRANSFER Registry is a prospective, international, web-based European Registry on Patients with ST-Elevation MI Transferred for Mechanical Reperfusion (PCI) with a Special Focus on Upstream Use of Abciximab.

This registry is designed to collect data on approximately 1800 patients during a 12 month enrollment period in up to 20 interventional cardiology centres with hospital transfer networks from all over Europe.

Analysis of this registry should allow to monitor transfer timelines of patients arriving to the cath-lab from the regional hospital with or without upstream start of abciximab and scheduled for mechanical reperfusion (PCI) as well as to monitor regional differences across Europe in regard to the impact that time of various stages of the treatment chain may have on clinical outcomes.

Detailed Description

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Conditions

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ST-Elevation Myocardial Infarction Acute Coronary Syndrome

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

PATIENTS:

* All consecutive STEMI patients \>=18years arriving to the Cath Lab hospital (invasive facility center) from transfer.

* Transfer with respect to this registry is defined as patients that reach the Cath Lab hospital:

1. transferred from a surrounding regional community hospitals that the Cath Lab hospital has an established referral pattern with or
2. after being picked-up by an ambulance which is equipped/staffed to provide specific medical therapy (like prehospital thrombolysis or upstream abciximab). Usually these have a physician or specifically trained nurse on board.

CENTRES:
* Provide 24 hour/7 days on duty PCI service.
* Has an established regional hospital referral network with \>=8 patients/month arriving from transfer (as defined above).
* A rate of \>=10% of these transfer patients who receive upstream abciximab before or during transfer to the Cath Lab hospital. Start of abciximab in the ER or CCU of the Cath Lab hospital will not be considered as upstream start of abciximab.

Exclusion Criteria

* Patients who arrive to the Cath Lab from other pathways than those specified above (a. and b.), e.g. those who come by ambulances that do not provide specific medical therapy or arrive directly to the ER of the Cath Lab hospital by own feet/car will not be included in this registry.
* Patients from controlled clinical trials shall be included as long as their actual treatment is fully known. Thus, participants from randomized trials with blinded treatment cannot be included in this registry.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Foundation for Medical Research in Krakow, Poland

UNKNOWN

Sponsor Role collaborator

Jagiellonian University

OTHER

Sponsor Role lead

Principal Investigators

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Dariusz Dudek, Assoc. Prof.

Role: PRINCIPAL_INVESTIGATOR

Cardiac Catheterization Laboratories, Jagiellonian University Medical College

Zbigniew Siudak, MD

Role: STUDY_CHAIR

Cardiac Catheterization Laboratories, Jagiellonian University Medical College

Lukasz Partyka, MD, PhD

Role: STUDY_DIRECTOR

KCRI

Locations

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Helsinki University Central Hospital

Helsinki, , Finland

Site Status

Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH

Villingen, , Germany

Site Status

San Donato Hospital

Arezzo, , Italy

Site Status

Ospedale Carlo Poma

Mantova, , Italy

Site Status

Ospedale G.Pasquinucci

Massa, , Italy

Site Status

Santa Maria Nuova Hospital Reggio Emilia

Reggio Emilia, , Italy

Site Status

Ospedale S.Maria di Ca Foncello

Treviso, , Italy

Site Status

Cardiac Catheterization Laboratories Jagiellonian University Medical College, University Hospital

Krakow, , Poland

Site Status

Department of Interventional Cardiology, John Paul II Hospital

Krakow, , Poland

Site Status

Szpital Wojewodzki w Przemyslu

Przemyśl, , Poland

Site Status

Szpital im. Szczeklika Tarnow

Tarnów, , Poland

Site Status

University Medical Center Ljubljana

Ljubljana, , Slovenia

Site Status

Hospital Juan Canalejo

A Coruña, , Spain

Site Status

Hospital Clinico Universitario

Santiago de Compostela, , Spain

Site Status

Linköping University Hospital

Linköping, , Sweden

Site Status

Countries

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Finland Germany Italy Poland Slovenia Spain Sweden

References

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Dziewierz A, Siudak Z, Rakowski T, Kleczynski P, Zasada W, Dubiel JS, Dudek D. Impact of direct stenting on outcome of patients with ST-elevation myocardial infarction transferred for primary percutaneous coronary intervention (from the EUROTRANSFER registry). Catheter Cardiovasc Interv. 2014 Nov 15;84(6):925-31. doi: 10.1002/ccd.25266. Epub 2014 Jul 29.

Reference Type DERIVED
PMID: 24155092 (View on PubMed)

Dziewierz A, Siudak Z, Rakowski T, Kleczynski P, Dubiel JS, Dudek D. Early administration of abciximab reduces mortality in female patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (from the EUROTRANSFER Registry). J Thromb Thrombolysis. 2013 Oct;36(3):240-6. doi: 10.1007/s11239-012-0826-3.

Reference Type DERIVED
PMID: 23065325 (View on PubMed)

Dziewierz A, Mielecki W, Siudak Z, Rakowski T, Janzon M, Birkemeyer R, Zasada W, Dubiel JS, Dudek D. Early abciximab administration before primary percutaneous coronary intervention improves clinical outcome in diabetic patients with ST-segment elevation myocardial infarction (EUROTRANSFER Registry). Atherosclerosis. 2012 Jul;223(1):212-8. doi: 10.1016/j.atherosclerosis.2012.04.018. Epub 2012 May 15.

Reference Type DERIVED
PMID: 22658254 (View on PubMed)

Siudak Z, Zawislak B, Dziewierz A, Rakowski T, Jakala J, Bartus S, Noworolnik B, Zasada W, Dubiel JS, Dudek D. Transradial approach in patients with ST-elevation myocardial infarction treated with abciximab results in fewer bleeding complications: data from EUROTRANSFER registry. Coron Artery Dis. 2010 Aug;21(5):292-7. doi: 10.1097/MCA.0b013e32833aa6d1.

Reference Type DERIVED
PMID: 20453640 (View on PubMed)

Dudek D, Siudak Z, Janzon M, Birkemeyer R, Aldama-Lopez G, Lettieri C, Janus B, Wisniewski A, Berti S, Olivari Z, Rakowski T, Partyka L, Goedicke J, Zmudka K; EUROTRANSFER Registry Investigators. European registry on patients with ST-elevation myocardial infarction transferred for mechanical reperfusion with a special focus on early administration of abciximab -- EUROTRANSFER Registry. Am Heart J. 2008 Dec;156(6):1147-54. doi: 10.1016/j.ahj.2008.08.004. Epub 2008 Oct 19.

Reference Type DERIVED
PMID: 19033011 (View on PubMed)

Other Identifiers

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H4S-PL-O067

Identifier Type: -

Identifier Source: org_study_id