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NCT00377169

Collection of Blood Samples From SMART Study Participants for Future Genetic Studies

Last Updated: 2016-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3261 participants

Study Classification

OBSERVATIONAL

Study Completion Date

2006-01-31

Brief Summary

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The purpose of this study is to collect blood samples from SMART study participants to use in future genetic studies.

Detailed Description

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Despite progress in the treatment of HIV and a greater understanding of the pathophysiology of HIV infection, there are still unexplained differences in both the progression of untreated HIV infection and response to antiretroviral therapy. These differences are likely related to the unique genetic makeup of individuals with HIV infection. Particular genes may offer protection against HIV infection, while other genes may make disease progression more likely. Knowing more about the genetic makeup of HIV infected individuals may lead to the development of a targeted treatment strategy based on an individual's specific risk of disease progression and sensitivity to medication toxicity. The purpose of this substudy is to collect blood samples from SMART study participants. The samples will be used in future Community Programs for Clinical Research on AIDS (CPCRA) studies investigating the link between human genetic factors and clinical outcome data.

This study will enroll individuals currently participating in the SMART study. Participants will provide one blood sample. Individual test results from future blood analyses will not be provided to a patient unless they may have profound health implications for that patient.

Conditions

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HIV Infections

Keywords

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Treatment Experienced

Eligibility Criteria

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Inclusion Criteria

* Coenrollment in the SMART study
* Parent or guardian willing to provide informed consent, if applicable

Minimum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Principal Investigators

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Jonathan Uy, MD

Role: STUDY_CHAIR

AIDS Research Alliance Chicago (ARAC), University of Illinois at Chicago

Roberto Arduino, MD

Role: STUDY_CHAIR

The University of Texas Health Science Center, Houston

Fraser Drummond, MBChB, MRCA, DA (UK)

Role: STUDY_CHAIR

National Centre in HIV Epidemiology and Clinical Research, University of New South Wales

Daniela Gey, MD

Role: STUDY_CHAIR

Copenhagen HIV Programme, Hvidovre University Hospital

Adrian Palfreeman, MD

Role: STUDY_CHAIR

Peterborough and Stamford Hospitals NHS Foundation Trust

Locations

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AltaMed Health Services Corporation

Los Angeles, California, United States

Site Status

Los Angeles Gay & Lesbian Community Service Center

Los Angeles, California, United States

Site Status

VA Greater Los Angeles Healthcare System

Los Angeles, California, United States

Site Status

VA Greater Loss Angeles Healthcare System

Los Angeles, California, United States

Site Status

Comprehensive Care Center/North Broward Hospital

Fort Lauderdale, Florida, United States

Site Status