Comparison of I-124 PET/CT, F-18 FDG PET/CT & I-123 Whole Body Scintigraphy for Recurrent Thyroid CA

NCT ID: NCT00373711

Last Updated: 2022-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2007-05-31

Brief Summary

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The management of thyroid cancer patients with suspicion of recurrent disease based on rising/detectable levels of thyroglobulin (Tg) involves imaging with iodine-123 whole body scintigraphy (I-123 WBS) and F-18 FDG PET/CT. However, the disease is not always detected. The use of another iodine isotope (I-124) with positron emitting characteristics for PET/CT may allow better identification of recurrent disease, thus allowing for more patients to be treated with I-131 as a curative attempt.

Detailed Description

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The management of thyroid cancer patients with suspicion of recurrent disease based on rising/detectable levels of thyroglobulin (Tg) involves imaging with iodine-123 whole body scintigraphy (I-123 WBS) and F-18 FDG PET/CT. However, the disease is not always detected. The use of another iodine isotope (I-124) with positron emitting characteristics for PET/CT may allow better identification of recurrent disease, thus allowing for more patients to be treated with I-131 as a curative attempt.

Conducting this study we hope to find whether I-124 PET/CT allows for detection of more lesions in patients with suspected recurrent thyroid cancer than the current standard of care represented by I-123 WBS and F-18 FDG PET/CT.

Conditions

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Thyroid Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Iodine-124

2 mCi, oral

Intervention Type DRUG

Iodine-123

2 mCi, oral

Intervention Type DRUG

F-18 FDG

10-15 mCi, iv

Intervention Type DRUG

Other Intervention Names

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Eastern Isotopes MDS Nordion Fludeoxyglucose (18 F) fluorodeoxyglucose (18 F) MIPS

Eligibility Criteria

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Inclusion Criteria

* Treated thyroid cancer.
* Detectable levels of Tg.
* Referred for I-123 WBS and F-18 FDG PET/CT for detection of recurrent thyroid cancer.
* Able to have a I-124 PET/CT the day after I-123 WBS and F-18 FDG PET/CT
* Patients older than 18-year-old.
* Patients with history of treated thyroid cancer and suspected recurrent thyroid cancer based on detectable levels of Tg.
* Patients must have I-123 WBS and F-18 FDG PET/CT performed prior to the I-124 PET/CT.

Exclusion Criteria

* Patients who cannot complete I-123 WBS and F-18 FDG PET/CT.
* Pregnant women.
* Healthy volunteers.
* Patients participating in other research studies.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Stanford University School of Medicine

Principal Investigators

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Andrei Iagaru

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Iain Ross McDougall

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Other Identifiers

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97454

Identifier Type: OTHER

Identifier Source: secondary_id

END0003

Identifier Type: OTHER

Identifier Source: secondary_id

END0003

Identifier Type: -

Identifier Source: org_study_id

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