The Effect of American Ginseng Root and Its Components on Glycemia in Healthy Individuals
NCT ID: NCT00367926
Last Updated: 2006-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
12 participants
INTERVENTIONAL
2005-06-30
2005-07-31
Brief Summary
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Detailed Description
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We therefore undertook a double-blind randomized controlled clinical trial to determine the effect of American ginseng root polysaccharides, at escalating doses, on postprandial glycemia, in comparison to the American ginseng root and control in healthy individuals. We hypothesized that polysaccharides will reduce glycemia comparably to a dose of ginseng root that contains polysaccharides at an equivalent amount to the average polysaccharide dose. We therefore tested polysaccharide doses equivalent to 9, 12 and 15 g of rot, 12 go of ginseng root and a wheat bran control. Each subject received each treatment in random sequence, after a 12-hour overnight fast and 40 minutes prior to a 25-g oral glucose tolerance test. Capillary blood samples were collected at baseline, prior to glucose ingestion and at 15, 30, 45, 60, 90, 120 minutes after the start of glucose intake. Capillary blood glucose was measured.
Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Interventions
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American ginseng root / polysaccharides
Eligibility Criteria
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Inclusion Criteria
* normal renal and hepatic function
* fasting plasma glucose: 4-6 mmol/l
* clinically euthyroid
* normotensive
Exclusion Criteria
* taking herbs, supplements or medication that affect glycemia
* major illnesses/ disease
* heavy alcohol use (\> 3 drinks/ day)
* heavy smoking (\> 10 cigarettes/ day)
16 Years
65 Years
ALL
Yes
Sponsors
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Canadian Institutes of Health Research (CIHR)
OTHER_GOV
Ontario Ginseng Growers Association
OTHER
Risk Factor Modification Centre
OTHER
Principal Investigators
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Vladimir Vuksan, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
St. Michael's Hospital/ University of Toronto
Locations
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Risk Factor Modification Centre
Toronto, Ontario, Canada
Countries
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Other Identifiers
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MOP- 62943
Identifier Type: -
Identifier Source: secondary_id
RFMC-0001-103
Identifier Type: -
Identifier Source: org_study_id