Registry for Acute Decompensated Heart Failure Patients

NCT ID: NCT00366639

Last Updated: 2009-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24118 participants

Study Classification

OBSERVATIONAL

Study Start Date

2001-10-31

Study Completion Date

2006-02-28

Brief Summary

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The purpose of the ADHERE study is to develop a multi-center, observational, open-label registry of the management strategies of patients treated in the hospital for acute Heart Failure in the United States.

Detailed Description

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The objective is to compile a clinical database on the strategy for the medical management of patients hospitalized with acute Heart Failure (HF). Through the use of the information collected from acute care hospitals across the United States the following information may be coming out of this study: 1) Assist hospitals in evaluating and improving quality of care for patients with acute HF by tracking quality indicators and providing benchmark data reports; 2) Describe the demographic and clinical characteristics of patients who are hospitalized with acute HF; 3) Characterize the initial emergency department evaluation and subsequent inpatient management of patients hospitalized with acute HF; 4) Identify patient characteristics and medical care practices associated with improved health outcomes in those hospitalized with acute HF; 5) Characterize trends and changes over time in the management of acute HF; 6) Offer surveillance of adherence to practice guidelines as these emerge for the inpatient management of acute HF. Observational Study - No investigational drug administered

Conditions

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Heart Failure, Congestive Heart Decompensation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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001

Acute Decompensated Heart Failure

Intervention Type OTHER

Treatment \& outcomes during hospital admission for Acute DHF

Interventions

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Acute Decompensated Heart Failure

Treatment \& outcomes during hospital admission for Acute DHF

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age greater than or equal to 18 years at the time of admission to the hospital
* Received or is eligible to receive a principal hospital discharge diagnosis of HF
* Decompensated HF is present as determined clinically by the patient care team

Exclusion Criteria

* HF is present as a co-morbid condition, but is not a principal focus of diagnosis or treatment during this hospitalization episode
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Scios, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Scios

Principal Investigators

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Scios, Inc. Clinical Trial

Role: STUDY_DIRECTOR

Scios, Inc.

References

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Kociol RD, Hammill BG, Fonarow GC, Klaskala W, Mills RM, Hernandez AF, Curtis LH. Generalizability and longitudinal outcomes of a national heart failure clinical registry: Comparison of Acute Decompensated Heart Failure National Registry (ADHERE) and non-ADHERE Medicare beneficiaries. Am Heart J. 2010 Nov;160(5):885-92. doi: 10.1016/j.ahj.2010.07.020.

Reference Type DERIVED
PMID: 21095276 (View on PubMed)

Maisel AS, Peacock WF, McMullin N, Jessie R, Fonarow GC, Wynne J, Mills RM. Timing of immunoreactive B-type natriuretic peptide levels and treatment delay in acute decompensated heart failure: an ADHERE (Acute Decompensated Heart Failure National Registry) analysis. J Am Coll Cardiol. 2008 Aug 12;52(7):534-40. doi: 10.1016/j.jacc.2008.05.010.

Reference Type DERIVED
PMID: 18687247 (View on PubMed)

Kamath SA, Drazner MH, Wynne J, Fonarow GC, Yancy CW. Characteristics and outcomes in African American patients with decompensated heart failure. Arch Intern Med. 2008 Jun 9;168(11):1152-8. doi: 10.1001/archinte.168.11.1152.

Reference Type DERIVED
PMID: 18541822 (View on PubMed)

Peacock WF 4th, De Marco T, Fonarow GC, Diercks D, Wynne J, Apple FS, Wu AH; ADHERE Investigators. Cardiac troponin and outcome in acute heart failure. N Engl J Med. 2008 May 15;358(20):2117-26. doi: 10.1056/NEJMoa0706824.

Reference Type DERIVED
PMID: 18480204 (View on PubMed)

Fonarow GC, Peacock WF, Horwich TB, Phillips CO, Givertz MM, Lopatin M, Wynne J; ADHERE Scientific Advisory Committee and Investigators. Usefulness of B-type natriuretic peptide and cardiac troponin levels to predict in-hospital mortality from ADHERE. Am J Cardiol. 2008 Jan 15;101(2):231-7. doi: 10.1016/j.amjcard.2007.07.066. Epub 2007 Dec 3.

Reference Type DERIVED
PMID: 18178412 (View on PubMed)

Hauptman PJ, Goodlin SJ, Lopatin M, Costanzo MR, Fonarow GC, Yancy CW. Characteristics of patients hospitalized with acute decompensated heart failure who are referred for hospice care. Arch Intern Med. 2007 Oct 8;167(18):1990-7. doi: 10.1001/archinte.167.18.1990.

Reference Type DERIVED
PMID: 17923600 (View on PubMed)

Fonarow GC, Peacock WF, Phillips CO, Givertz MM, Lopatin M; ADHERE Scientific Advisory Committee and Investigators. Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure. J Am Coll Cardiol. 2007 May 15;49(19):1943-50. doi: 10.1016/j.jacc.2007.02.037. Epub 2007 Apr 30.

Reference Type DERIVED
PMID: 17498579 (View on PubMed)

Other Identifiers

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CR005194

Identifier Type: -

Identifier Source: org_study_id

NCT00530673

Identifier Type: -

Identifier Source: nct_alias

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