Pioglitazone and Losartan Provides Additional Renoprotection

NCT ID: NCT00364988

Last Updated: 2014-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-01-31

Study Completion Date

2006-01-31

Brief Summary

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Peroxisomal proliferator-activated receptor agonist pioglitazone and rosiglitazone are currently used in the treatment of type 2 diabetes, as efficient insulin sensitizers alone or in combination with insulin.angiotensin II receptor antagonist losartan reduced the levels of proteinuria.Whether Combination therapy with pioglitazone and losartan provides additional renoprotection in subjects with type 2 diabetic nephropathy,it's worth researching.

Detailed Description

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Conditions

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Type 2 Diabetes Diabetic Nephropathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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pioglitazone+losartan

Pioglitazone (30 mg/daily) losartan (100 mg daily)

Intervention Type DRUG

losartan

losartan (100 mg daily)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Fasting plasma glucose (FPG) level of 3.3-9.0mmol/L
* 2h plasma glucose level of 7.5-13 mmol/L
* serum creatinine values between 190 and 660umol/L
* Two occasions of a ratio of urinary albumin to urinary creatinine≥300 or 24 hours urinary protein concentration is \>150mg
* Informed consent

Exclusion Criteria

* Type1 diabetes or nondiabetic renal disease
* abnormal liver function
* heart dysfunction
Minimum Eligible Age

32 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Hui Min Jin

Chief,department of Nephrology,shanghai No.3 people's hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hui M Jin, MD

Role: PRINCIPAL_INVESTIGATOR

Shanghai No.3 People's Hospital

Other Identifiers

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PLAN

Identifier Type: -

Identifier Source: org_study_id

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