Dose Finding Study of KRN125 (Pegfilgrastim) for Treatment of Neutropenic Patients

NCT ID: NCT00364468

Last Updated: 2017-03-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

107 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-03-31

Study Completion Date

2008-03-31

Brief Summary

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To assess the duration of severe neutropenia in cycle 1 of chemotherapy after treatment with a single injection of KRN125 or multiple daily injections of filgrastim.

Detailed Description

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Conditions

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Neutropenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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pegfilgrastim

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patients diagnosed as malignant lymphoma
* patients who were refractory to anthracycline or anthraquinone containing chemotherapy
* patients who are going to receive ESHAP or CHASE treatment regimen
* ECOG performance status =\< 2
* patients who have appropriate bone marrow, hepatic and renal functions
* written informed consent

Exclusion Criteria

* double cancer
* history of bone marrow transplantation or PBSCT
* more than 2 prior chemotherapy regimens
* primary hematologic disease such as myelodysplastic syndrome
* previous radiotherapy within 4 weeks of enrollment
* woman of childbearing potential who were either pregnant, breast feeding
* patients who participated in other clinical trials within the last 4 weeks of enrollment
Minimum Eligible Age

20 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kyowa Kirin Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tomomitsu Hotta, MD

Role: STUDY_CHAIR

Nagoya Medical Center

Locations

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Tokai region

Aichi, , Japan

Site Status

Kyusyu region

Fukuoka, Nagasaki, , Japan

Site Status

Kanto region

Gunma, Saitama, Tokyo, Kanagawa, , Japan

Site Status

Hokkaido region

Hokkaido, , Japan

Site Status

Kinki region

Kyoto, Mie, Shiga, , Japan

Site Status

Tohoku region

Miyagi, , Japan

Site Status

Countries

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Japan

Other Identifiers

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KRN125/05-A04

Identifier Type: -

Identifier Source: org_study_id

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